Interleukin-7: an interleukin for rejuvenating the immune system

Annals of the New York Academy of Sciences
Richard AspinallPa Tamba Ngom

Abstract

Infection of an individual (aged 20-30 years) by a virus will cause a response from the T (thymus derived) lymphocytes of which there are approximately 3 x 10(11). If the individual has not met the virus before, the response will come from the naive T cell subset (50 +/- 10% of the total T cell pool at this age) containing recent thymic emigrants produced from the thymus at approximately 10(8) per day. Their antigen-specific receptor has a defined specificity governed by the conformation of its two chains (alpha and beta), and the repertoire of specificities is somewhere in the region of 2 x 10(7) to 10(8). A successful response leads to clonal expansion and the generation of memory T cells to the infecting agent.

References

Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·N P WengR J Hodes
Feb 1, 1997·Mechanisms of Ageing and Development·M UtsuyamaK Hirokawa
Jun 1, 1997·Mechanisms of Ageing and Development·M L Thoman
Jul 6, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T T Yoshikawa
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D Andrew, R Aspinall
Sep 28, 2001·Trends in Immunology·T J Fry, C L Mackall
Oct 2, 2002·European Journal of Immunology·Jeffrey Pido-LopezRichard Aspinall

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Citations

Apr 13, 2006·Rejuvenation Research·Graham PawelecAnders Wikby
Sep 4, 2009·Rejuvenation Research·Johannes HoferMartina Prelog
Aug 14, 2009·Rejuvenation Research·Manuela Zlamy, Martina Prelog
Jun 4, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Asa AnderssonSherven Sharma
Feb 29, 2008·Experimental & Molecular Medicine·Hee Woo LeeSik Yoon
Jun 23, 2009·Trends in Immunology·Kohtaro Fujihashi, Hiroshi Kiyono
Feb 27, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Betty LiKarin Jooss
Aug 10, 2010·Transplant Immunology·Atsushi HirakataKazuhiko Yamada
Nov 6, 2004·Blood Cells, Molecules & Diseases·Franco AversaMassimo F Martelli
May 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janet E McElhaneyR Chris Bleackley
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Asa AnderssonSherven Sharma

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