Interleukin-7 is required for CD4(+) T cell activation and autoimmune neuroinflammation

Clinical Immunology : the Official Journal of the Clinical Immunology Society
Brian R LawsonArgyrios N Theofilopoulos

Abstract

IL-7 is known to be vital for T cell homeostasis but has previously been presumed to be dispensable for TCR-induced activation. Here, we show that IL-7 is critical for the initial activation of CD4(+) T cells in that it provides some of the necessary early signaling components, such as activated STAT5 and Akt. Accordingly, short-term in vivo IL-7Rα blockade inhibited the activation and expansion of autoantigen-specific CD4(+) T cells and, when used to treat experimental autoimmune encephalomyelitis (EAE), prevented and ameliorated disease. Our studies demonstrate that IL-7 signaling is a prerequisite for optimal CD4(+) T cell activation and that IL-7R antagonism may be effective in treating CD4(+) T cell-mediated neuroinflammation and other autoimmune inflammatory conditions.

References

Apr 1, 1995·The Journal of Experimental Medicine·U von Freeden-JeffryR Murray
Mar 29, 2000·Proceedings of the National Academy of Sciences of the United States of America·H WaldnerV K Kuchroo
Jul 12, 2001·Proceedings of the National Academy of Sciences of the United States of America·J T TanC D Surh
May 30, 2002·Cellular Signalling·Eva RajnavolgyiScott K Durum
Jun 8, 2002·Annual Review of Neuroscience·Lawrence SteinmanJorge R Oksenberg
Nov 5, 2002·Nature Reviews. Immunology·Annette R Khaled, Scott K Durum
Jun 17, 2003·Nature Immunology·Benedict SeddonRose Zamoyska
Nov 25, 2003·European Journal of Immunology·Niels Olsen Saraiva CâmaraRobert I Lechler
May 5, 2004·The Journal of Biological Chemistry·Wen Qing LiScott K Durum
Oct 27, 2004·The Journal of Experimental Medicine·Marc PellegriniAndreas Strasser
Jan 22, 2005·Neurologic Clinics·Amit Bar-Or
Mar 1, 2005·Nature Medicine·Eileen J McMahonStephen D Miller
Jul 6, 2005·Cytokine & Growth Factor Reviews·Qiong JiangScott K Durum
Jul 5, 2006·The Journal of Experimental Medicine·Nabila SeddikiBarbara Fazekas de St Groth
Jul 5, 2006·The Journal of Experimental Medicine·Weihong LiuJeffrey A Bluestone
Jan 30, 2007·Nature Reviews. Immunology·Renata Mazzucchelli, Scott K Durum
Feb 22, 2007·The Journal of Experimental Medicine·Hans DoomsAbul K Abbas
Apr 11, 2007·Acta Neurologica Scandinavica. Supplementum·T Holmøy
Jul 31, 2007·The New England Journal of Medicine·UNKNOWN International Multiple Sclerosis Genetics ConsortiumStephen L Hauser
Jul 31, 2007·Nature Genetics·Simon G GregoryUNKNOWN Multiple Sclerosis Genetics Group
Sep 5, 2007·Cytokine·Christina Kittipatarin, Annette R Khaled
Feb 5, 2008·Immunology Letters·Marisa M Juntilla, Gary A Koretzky
Apr 9, 2008·Journal of Neurology·Ralf Gold
Dec 23, 2008·Immunity·Charles D Surh, Jonathan Sprent
Mar 18, 2009·Immunological Reviews·David A Fruman, Georges Bismuth
Mar 5, 2010·American Journal of Physiology. Cell Physiology·Mounir Chehtane, Annette R Khaled
Sep 24, 2010·Genes and Immunity·C C WallineJ J Bright
Sep 3, 2011·European Journal of Immunology·Qianting YangBinfeng Lu
Jun 27, 2012·Proceedings of the National Academy of Sciences of the United States of America·Cristina PenarandaHans Dooms

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Citations

Oct 28, 2016·The Journal of Investigative Dermatology·Jutamas SuwanpradidAmanda S MacLeod
Feb 13, 2018·Apoptosis : an International Journal on Programmed Cell Death·Ingo GerhauserAndreas Beineke
Mar 27, 2020·Cellular & Molecular Immunology·Hee Yeun WonJung-Hyun Park
Jan 30, 2021·British Journal of Pharmacology·Giuseppe PignataroMaurizio Taglialatela
Aug 26, 2021·SAR and QSAR in Environmental Research·J-Y LeeB Koh

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