PMID: 8938103Dec 1, 1996Paper

Interleukin-7 modulates intracytoplasmatic CD23 production and induces adhesion molecule expression and adhesiveness in activated CD4+CD23+ T cell subsets

Clinical Immunology and Immunopathology
C Fratazzi, C Carini

Abstract

The low-affinity receptor for IgE, CD23, has been described in several pathological conditions. However, the factors involved in the upregulation or downregulation of this receptor are still debated. We studied the effect of interleukin 7 (IL-7) on the production of CD23 in normal PBT cells stimulated with PMA + Ca2. The results demonstrate that cytoplasmic CD23 level was significantly augmented by costimulation with PMA + Ca2 plus IL-7 (1000 U/ml). Using an intracytoplamatic cytometric analysis, an accumulation of intracellular CD23 was observed at 48 hr in the presence of IL-7. This appears to have a profile different from the CD23 surface expression peaking at 72 hr of culture. We were also able to show that sCD23 was specifically increased by IL-7 and occurred with an early peak at 72 hr and a late peak at 120 hr of culture. The increased release and the biphasic production of sCD23 may reside in an accelerated degradation of the receptor due to an excessive accumulation of it. Restimulation of CD4+ T cells with PMA + Ca2 without IL-7 changed the profile of sCD23 production showing a second peak at 144 hr of culture. The induction of IL-7 on CD23 production appears to be independent of IL-2, IL-4, IL-9, and IL-15. Indeed, t...Continue Reading

Citations

Apr 4, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Mitsuhiro OkanoKazunori Nishizaki
Aug 28, 2016·Respiratory Investigation·Masaya TakemuraMotonari Fukui
Feb 13, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·M M GrunsteinS Chuang
Jun 3, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·M M GrunsteinS Chuang

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