PMID: 9449719Mar 21, 1998Paper

Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa

The Journal of Experimental Medicine
M WatanabeT Hibi

Abstract

We have demonstrated that intestinal epithelial cells produce interleukin 7 (IL-7), and IL-7 serves as a potent regulatory factor for proliferation of intestinal mucosal lymphocytes expressing functional IL-7 receptor. To clarify the mechanism by which locally produced IL-7 regulates the mucosal lymphocytes, we investigated IL-7 transgenic mice. Here we report that transgenic mice expressing murine IL-7 cDNA driver by the SRalpha promoter developed chronic colitis in concert with the expression of SRalpha/IL-7 transgene in the colonic mucosa. IL-7 transgenic but not littermate mice developed chronic colitis at 4-12 wk of age, with histopathological similarity to ulcerative colitis in humans. Southern blot hybridization and competitive PCR demonstrated that the expression of IL-7 messenger RNA was increased in the colonic mucosal lymphocytes but not in the colonic epithelial cells. IL-7 protein accumulation was decreased in the goblet cell-depleted colonic epithelium in the transgenic mice. Immunohistochemical and cytokine production analysis showed that lymphoid infiltrates in the lamina propria were dominated by T helper cell type 1 CD4+ T cells. Flow cytometric analysis demonstrated that CD4+ intraepithelial T cells were incr...Continue Reading

References

Apr 1, 1992·European Journal of Immunology·M V WilesB A Imhof
Sep 26, 1991·The New England Journal of Medicine·D K Podolsky
Oct 3, 1991·The New England Journal of Medicine·D K Podolsky
Mar 1, 1989·The Journal of Experimental Medicine·P J MorrisseyS G Reed
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G GoodwinA E Namen
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G D ChazenE M Shevach
Mar 1, 1988·Immunology Today·C A JanewayA Hayday
Nov 1, 1995·The Journal of Experimental Medicine·M F NeurathW Strober
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·H C Reinecker, D K Podolsky
Sep 1, 1993·The Journal of Experimental Medicine·A PanjaL Mayer
Jan 1, 1993·Cancer Investigation·P M Appasamy
Sep 1, 1993·The Journal of Experimental Medicine·C HeuflerG Schuler
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·H IshikawaS Tonegawa

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Citations

Aug 1, 2008·Inflammatory Bowel Diseases·Takayuki TomitaMamoru Watanabe
Feb 5, 2004·Langenbeck's Archives of Surgery·Martin H Holtmann, Peter R Galle
Nov 18, 2000·Current Gastroenterology Reports·R C Fitzgerald, M J Farthing
Sep 12, 2000·Current Gastroenterology Reports·K A Papadakis, S R Targan
Jun 18, 1999·Gastroenterology Clinics of North America·K A Papadakis, S R Targan
Jan 13, 2000·Current Opinion in Immunology·R S BlumbergW Strober
Jun 24, 1999·Cytokine & Growth Factor Reviews·R HofmeisterS K Durum
Dec 12, 2001·The British Journal of Surgery·B SinghN J Mortensen
May 11, 2000·Pediatrics International : Official Journal of the Japan Pediatric Society·K KatamuraH Ueno
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Thomas CalzasciaTak W Mak
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Craig A McElroyScott T R Walsh
Jul 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Tobias Boettler, Matthias von Herrath
May 3, 2000·The Journal of Experimental Medicine·K LakyL Puddington
Feb 28, 2002·The Journal of Infectious Diseases·Oliver Liesenfeld
Oct 7, 2006·Current Opinion in Gastroenterology·A K BhanA Mizoguchi
Aug 7, 2003·Inflammatory Bowel Diseases·Atsushi MizoguchiAtul K Bhan
Mar 2, 2013·Inflammatory Bowel Diseases·Andreas JanssonElisabeth Hultgren Hörnquist
Aug 2, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Jan WalterGrace M Aldrovandi
Oct 3, 2007·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Joseph Wickham, Scott T R Walsh
Jan 21, 2004·Journal of Gastroenterology and Hepatology·Kenichi IshiiMamoru Watanabe
Nov 30, 2005·Molecular and Cellular Biology·Laura T DonlinKonstantina Alexandropoulos
Feb 28, 2002·Annual Review of Immunology·Warren StroberRichard S Blumberg
Apr 12, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hua YangDaniel H Teitelbaum
Jan 12, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hua YangDaniel H Teitelbaum
Oct 13, 2012·Journal of Inflammation·Cynthia R WillisLillian Maggio-Price
Mar 3, 2012·PloS One·Shabnam ShalapourThomas Schüler
Nov 20, 2013·Drug Design, Development and Therapy·Daren LowEmiko Mizoguchi
Dec 19, 2002·Drugs·Hiroyuki TakatsukaEizo Kakishita
Mar 4, 2005·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Rieko TsubataNobuyuki Miyasaka
Nov 1, 2006·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Mamoru Watanabe

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