PMID: 9176651May 1, 1997Paper

Interleukin-8 and leukotriene B4 in bronchoalveolar lavage fluid from HIV-infected patients with bacterial pneumonia

Respiratory Medicine
E KrarupJ D Lundgren

Abstract

Human immunodeficiency virus (HIV)-infected patients are at increased risk of contracting bacterial infections, mainly pneumonia. Despite this, little is known about immunopathogenic mechanisms in HIV-related bacterial pneumonia. This paper investigates the presence of the neutrophil chemotactic mediators, interleukin-8 (IL_8) and leukotriene B4 (LTB4), in bronchoalveolar lavage (BAL) fluid from 27 HIV-infected patients with bacterial pneumonia. Significantly elevated levels of IL-8 were found in BAL fluid of patients with bacterial pneumonia [529 pg ml-1 (296-1161 pg ml-1)] compared to matched patients with Pneumocystis carinii pneumonia (PCP) [59 pg ml-1 (42-254 pg ml-1)] and healthy controls [58 pg ml-1 (37-82 pg ml-1)]. Levels of LTB4 were not elevated during bacterial pneumonia when compared to PCP patients and healthy controls. Furthermore, a positive correlation was found between IL-8 levels in BAL fluid and relative BAL neutrophilia (r = 0.60, P = 0.001) in bacterial pneumonia. In conclusion, elevated IL-8 levels in BAL fluid were found in patients suffering from bacterial pneumonia, which may account for the influx of neutrophils to the lung, whereas LTB4 appears not to be an important chemotactic factor in this setting.

Citations

Aug 7, 1999·Clinical Reviews in Allergy & Immunology·M Peters-Golden, M Coffey
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·J A Hankin, R C Murphy
Dec 15, 2015·Pathogens and Disease·Gregory H TaylorAlfredo Garzino-Demo
Oct 30, 1998·The Journal of Laboratory and Clinical Medicine·M Peters-Golden, M Coffey
Oct 11, 2019·Physiological Reviews·Sushma K CribbsAlison Morris
Jan 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah G HarrisRichard P Phipps
Jan 7, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marc Peters-GoldenMichael J Coffey
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Louis FlamandPierre Borgeat
Nov 2, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Carlos Arterio SorgiLúcia Helena Faccioli

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