Interleukin 8 can affect inner ear function

ORL; Journal for Oto-rhino-laryngology and Its Related Specialties
H Iguchi, M Anniko

Abstract

The chemokine interleukin 8 (IL-8) was instilled into the round window niche of rats through a small perforation in the tympanic membrane in order to study its effect on inner ear function by electrophysiological and morphological techniques. The frequency-specific auditory brainstem response (ABR) was recorded at the frequencies 4, 8, 10, 12, 16 and 20 kHz just before and 1, 2, 5 and 14 days after instilling IL-8 to ascertain the hearing level during each interval. Morphological examination by light microscopy was performed during the same interval following the instillation of IL-8. On day 1, the rise in ABR threshold was within 5 dB SPL (non-significant elevation). However, a significant threshold elevation (above 5 dB SPL) occurred in high-frequency areas (16 and 20 kHz) on day 2, and in middle frequency areas (10 and 12 kHz) on day 5 with sensorineural hearing loss type intensity-latency curves. By day 14, the elevated thresholds had returned to pre-instillation levels. In the lowest areas (4 and 8 kHz), no significant threshold elevation was detected at any time during the observation period. By light microscopy, on day 1, clusters of inflammatory cells (predominantly neutrophils) were observed just outside the round wind...Continue Reading

Citations

Oct 4, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Vladimir TsuprunSteven K Juhn
Apr 1, 2005·Acta Oto-laryngologica·Sebahattin CureogluMichael M Paparella
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Frank HaubnerTobias Kleinjung
Jul 14, 2000·Acta Oto-laryngologica·N Takeuchi, M Anniko
Feb 11, 2005·The Annals of Otology, Rhinology & Laryngology. Supplement·Allen F RyanGarth D Ehrlich

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