Interleukin-8 expression in patients after renal transplantation

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
K BuddeH H Neumayer

Abstract

Cellular invasion and cytokine release are important steps in the initiation of rejection. We studied the release of interleukin-8 (IL-8), a potent proinflammatory and chemotactic cytokine, and its prognostic significance in predicting rejection after renal transplantation. Serum and urine samples were analyzed with an IL-8-specific sandwich enzyme-linked immunosorbent assay. Biopsy tissue specimens (n = 20) were snap-frozen and examined with immunohistochemistry using two monoclonal antibodies against human IL-8 (4G9 and 2A8). Serum IL-8 measurements were of no value in predicting rejection due to low sensitivity (24%). In 45 biopsy-proven acute rejections (< 2 months after transplantation), urinary IL-8 concentrations were elevated in 62% (298 +/- 54 pg/mL; P < 0.01), preceding clinical diagnosis of rejection. After treatment, the IL-8 concentration in urine decreased back to normal (33 +/- 4 pg/mL; P < 0.01). The highest urinary IL-8 concentrations were seen in patients with biopsy-proven rejection in combination with acute tubular necrosis (610 +/- 150 pg/mL). This finding was independent of renal function and urinary volume. Only three of 15 rejection episodes in patients more than 2 months after transplantation showed an ...Continue Reading

References

Apr 1, 1992·Transplantation·H TilgC Huber
Sep 1, 1992·The Journal of Clinical Investigation·A P MetinkoR M Strieter
Mar 1, 1992·Transplantation·J L TaupinJ H Bezian
Jan 1, 1992·Kidney International·R L SchmouderS L Kunkel
Jul 27, 1992·FEBS Letters·M Baggiolini, I Clark-Lewis
Jun 1, 1991·Transplantation·B M Hall
Jan 1, 1991·The Journal of Investigative Dermatology·M SticherlingE Christophers
Feb 1, 1992·The Journal of Investigative Dermatology·J M SchröderE Christophers
Jan 1, 1991·Annual Review of Immunology·J J OppenheimK Matsushima
Sep 1, 1991·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·J M WangA Mantovani
Jan 1, 1995·The Journal of Clinical Investigation·G L KukielkaM L Entman
Nov 1, 1994·Current Opinion in Nephrology and Hypertension·M C CuturiJ P Soulillou
Mar 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G H BockD L Nelson
Apr 1, 1994·The Journal of Clinical Investigation·M KarakurumD Stern
Oct 1, 1993·Current Opinion in Immunology·M J Dallman
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·K BuddeH H Neumayer

❮ Previous
Next ❯

Citations

Apr 29, 2005·Journal of the American Society of Nephrology : JASN·Ingeborg A HauserHeinfried H Radeke
Apr 21, 2007·Acta Physiologica Hungarica·M Fischereder
Sep 6, 2007·World Journal of Urology·Wilfried Gwinner
Jun 7, 2003·Transplantation·Kenji YuzawaNobuhiro Ohkohchi
May 12, 2017·Renal Failure·Ewa KwiatkowskaSebastian Kwiatkowski
Apr 17, 2003·Transplantation·Stephan SegererHeinz Regele
Jan 5, 2000·Journal of the American Society of Nephrology : JASN·Stephan SegererDetlef Schlöndorff
Jul 10, 2007·Seminars in Nephrology·Raffaele GirlandaAllan D Kirk

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.