Interleukin-8 in Hyperlipidemia and Coronary Heart Disease in Thai Patients Taking Statin Cholesterol-Lowering Medication While Undergoing Coronary Artery Bypass Grafting Treatment

Scientifica
Wilanee DechkhajornRatchanok Kumsiri

Abstract

The role of interleukin-8 (IL-8), a pivotal chemokine in atherogenesis and coronary heart disease (CHD) development, is diverse and remains unclear. This cross-sectional study investigates the association of the IL-8 expression in hyperlipidemia (H) and CHD patients who have been treated with statin cholesterol-lowering drugs while undergoing coronary artery bypass grafting treatment. Fifty-five Thai volunteers including 13 normal (N), 24 H, and 18 CHD patients were enrolled for the investigation. All the CHD patients had been treated continuously with statin cholesterol-lowering medications since the disease was diagnosed and were undergoing coronary bypass grafting approximately one month later. Therefore, the CHD group was representative of a pathogenesis improvement in CHD. The IL8 mRNA expression was determined by real-time quantitative PCR in the peripheral blood mononuclear cells from heparinized blood. The plasma IL-8 levels were assessed by enzyme-linked immunosorbent assay. The result shows that the IL8 mRNA expression in the H group tended to increase; however, in the CHD group, there was a significant decrease (p=0.0111) compared to the N group. The IL8 mRNA expression and the plasma levels in the CHD group were sig...Continue Reading

References

Dec 1, 1990·The Journal of Investigative Dermatology·J Van Damme, G Opdenakker
Jul 1, 1994·Circulation Research·T L YueG Z Feuerstein
Jan 5, 2002·Atherosclerosis·William S ShinStanley G Rockson
Apr 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mimi TakamiLilli Petruzzelli
Sep 24, 2002·International Journal of Cardiology·James K Liao
Dec 19, 2002·European Journal of Clinical Investigation·E RomukM Tendera
Feb 8, 2005·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·N G Frangogiannis
Sep 22, 2007·Current Opinion in Lipidology·Jean-François ArnalPierre Gourdy
Apr 22, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jennifer H YearleyKeith G Mansfield
May 30, 2009·Journal of cardiology·Epaminondas Zakynthinos, Nikolitsa Pappa
Aug 9, 2011·Pulmonary Pharmacology & Therapeutics·Sven van EijlNanne Bloksma
Nov 9, 2011·Nature Medicine·Christian Weber, Heidi Noels
Aug 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Peter Libby
Jun 19, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Xiangmin ZhaoYiu-Fai Chen
Jul 9, 2013·Biochemical and Biophysical Research Communications·Do-Hyung KimKoanhoi Kim
Jan 28, 2014·International Journal of Cardiology·Ilais Moreno VelásquezBruna Gigante
Mar 19, 2014·Atherosclerosis·Adam M Noyes, Paul D Thompson
May 26, 2015·Cytokine & Growth Factor Reviews·Dipak P Ramji, Thomas S Davies
Oct 27, 2015·International Journal of Oncology·Thanet SophonnithiprasertRamida Watanapokasin
Apr 1, 2017·Journal of Cardiothoracic Surgery·Yie Roei CheeDavid G Healy
Oct 4, 2018·Scandinavian Journal of Clinical and Laboratory Investigation·Marevic SanjaZidovec Lepej Snjezana

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
coronary bypass
PCR
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.