PMID: 9184952May 1, 1997Paper

Interleukin-8 level in maternal serum as a marker for screening of histological chorioamnionitis at term

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
K ShimoyaY Murata

Abstract

To establish a clinical method for immediate diagnosis of histological chorioamnionitis, by maternal blood sampling at term. The sera of 22 mothers with chorioamnionitis and 81 mothers without chorioamnionitis at term delivery were collected. The serum levels of cytokines including interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were titered and other conventional markers such as white blood cell and CRP were measured simultaneously. Chorioamnionitis was histopathologically confirmed after delivery. The sera of mothers with histological chorioamnionitis showed a significant increase in IL-8 titer, but not in those of other cytokines or conventional markers, compared with those without chorioamnionitis. A positive correlation was observed between maternal and cord serum IL-8 levels. Maternal IL-8 showed the highest predictive value for diagnosis of histological chorioamnionitis. Measurement of maternal IL-8 is useful for rapid prenatal screening of histological chorioamnionitis at term.

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Citations

Nov 27, 1999·Obstetrics and Gynecology·J C SmulianC V Ananth
Aug 5, 2000·Journal of Reproductive Immunology·F SajiT Kimura
Jun 5, 2003·Journal of Immunoassay & Immunochemistry·I SplichalE Takahashi
Dec 17, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Waleed Ali Sayed AhmedKhaled Mohamed Elnahas
Jun 5, 2003·Acta Obstetricia Et Gynecologica Scandinavica·Ahmed M BaharOsman A Nabri
Feb 11, 2011·Autoimmunity·Sabina Resic LindehammerUNKNOWN Diabetes and Celiac Disease Prediction in Scania Study Group
Jul 6, 2007·Expert Review of Neurotherapeutics·Justin D Penner, Alan S Brown
Apr 18, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Snjezana SkrablinDrzislav Kalafatic
Aug 21, 2012·Obstetrical & Gynecological Survey·Annemieke C C EversGerard H A Visser
Mar 10, 2001·Scandinavian Journal of Infectious Diseases·R MändarM Mikelsaar
Jul 3, 2021·Journal of Clinical Medicine·Joon-Hyung LeeJong-Kwan Jun

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