Interleukin-8 secretion by ovarian cancer cells increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion

Cytokine
Yue WangXiang Yan Meng

Abstract

It has been shown that IL-8 is elevated in ovarian cyst fluid, ascites, serum, and tumor tissue from ovarian cancer (OVCA) patients, and increased IL-8 expression correlates with poor prognosis and survival. However, the exact role that IL-8 plays in this malignancy or whether IL-8 can regulate malignant behavior has not been established. Here we demonstrate that overexpression of IL-8 in non-IL-8-expressing A2780 cells (by transfecting with plasmid encoding for sense IL-8) increases anchorage-independent growth, proliferation, angiogenic potential, adhesion and invasion while depletion of endogenous IL-8 expression in IL-8-overexpressing SKOV-3 cells (by transfecting with plasmid encoding for antisense IL-8) decreases the above effects. Further investigation indicates that IL-8-stimulated cell proliferation correlates with alteration of cell cycle distribution by increasing levels of cell cycle-regulated Cyclin D1 and Cyclin B1 proteins as well as activation of PI3K/Akt and Raf/MEK/ERK, whereas IL-8-enhanced OVCA cell invasive correlates with increased MMP-2 and MMP-9 activity and expression. Our data suggest that IL-8 secreted by OVCA cells promotes malignant behavior of these cells via inducing intracellular molecular signal...Continue Reading

References

Jul 1, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K A Roebuck
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R. T. PensonM. V. Seiden
Jun 1, 2001·Fertility and Sterility·A FascianiA R Genazzani
Sep 7, 2001·Cytokine & Growth Factor Reviews·K Xie
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Kerstin LangFrank Entschladen
Jul 2, 2003·Nature Reviews. Cancer·Roshan Agarwal, Stan B Kaye
Apr 13, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R UsluE Goker
Jun 17, 2005·Cancer Science·Toshiyuki TanakaMasayuki Miyasaka
Jan 26, 2006·Gynecologic Oncology·Anna E LokshinElieser Gorelik
Dec 19, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·F LuppiP S Hiemstra
Jul 4, 2007·Molecular Cancer Research : MCR·Christopher F MacManusDavid J J Waugh
Jul 11, 2007·International Journal of Cancer. Journal International Du Cancer·Chen YaoShen-Ming Wang
Sep 11, 2007·Cancer Metastasis Reviews·Seema SinghRakesh K Singh
Feb 22, 2008·Current Cancer Drug Targets·George Z ChengJin Q Cheng
Mar 4, 2008·Journal of the National Cancer Institute·William M MerrittAnil K Sood
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David J J Waugh, Catherine Wilson

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Citations

Jan 16, 2014·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Jennifer PasquierArash Rafii
Mar 29, 2014·Cancer Investigation·Paul ZarogoulidisKonstantinos Zarogoulidis
Apr 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Ming T CheahIrving L Weissman
Sep 24, 2015·Journal of Receptor and Signal Transduction Research·Anna JesionowskaBarbara Dolegowska
Apr 16, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Carol BoxSuzanne A Eccles
Dec 21, 2014·Gynecologic Oncology·Sharon L EddieJoanna E Burdette
Dec 3, 2014·Gynecologic Oncology·Claire BonneauCyril Touboul
Aug 26, 2014·Cytokine·D KoensgenA Mustea
Nov 6, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sangmin KimSeok Jin Nam
May 25, 2016·The American Journal of Pathology·Jennifer M CaronPeter C Brooks
Oct 27, 2016·Memórias do Instituto Oswaldo Cruz·Sérgio Ferreira de LimaSergio Crovella
Sep 30, 2017·Scandinavian Journal of Immunology·A Martins-FilhoR S Nomelini
Mar 10, 2018·Molecular and Cellular Biochemistry·Wenying ZhangChengbin Ma
Feb 11, 2015·World Journal of Gastroenterology : WJG·Jun Shi, Pin-Kang Wei
Jul 4, 2019·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Dulce Rosario Alberto-AguilarPatricia Talamás-Rohana
Sep 6, 2017·Immunological Investigations·Marcela Moisés Maluf SanguineteRosekeila Simões Nomelini
Aug 13, 2015·Oncotarget·Bipradeb SinghaIvana Vancurova
Feb 20, 2016·Oncology Letters·Jun Shi, Pin-Kang Wei
Sep 21, 2017·Oncology Letters·Xiaolin YuRensheng Chen
Mar 27, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gregory D ConwayToni M Antalis
Oct 5, 2018·Journal of Translational Medicine·Jennifer PasquierArash Rafii

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