Interleukin-9 Deletion Relieves Vascular Dysfunction and Decreases Blood Pressure via the STAT3 Pathway in Angiotensin II-Treated Mice

Mediators of Inflammation
Yunzhao YangHexiang Chen

Abstract

Multiple interleukin (IL) family members were reported to be closely related to hypertension. We aimed to investigate whether IL-9 affects angiotensin II- (Ang II-) induced hypertension in mice. Mice were treated with Ang II, and IL-9 expression was determined. In addition, effects of IL-9 knockout (KO) on blood pressure were observed in Ang II-infused mice. To determine whether the effects of IL-9 on blood pressure was mediated by the signal transducer and activator of the transcription 3 (STAT3) pathway, Ang II-treated mice were given S31-201. Furthermore, circulating IL-9 levels in patients with hypertension were measured. Ang II treatment increased serum and aortic IL-9 expression in a dose-dependent manner; IL-9 levels were the highest in the second week and continued to remain high into the fourth week after the treatment. IL-9 KO downregulated proinflammatory cytokine expression, whereas it upregulated anti-inflammatory cytokine levels, relieved vascular dysfunction, and decreased blood pressure in Ang II-infused mice. IL-9 also reduced smooth muscle 22α (SM22α (SM22. IL-9 KO alleviates inflammatory response, prevents phenotypic transformation of smooth muscle, reduces vascular dysfunction, and lowers blood pressure via ...Continue Reading

References

Nov 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Dexter L LeeMichael W Brands
Dec 30, 2009·Hypertension·Meena S MadhurDavid G Harrison
Dec 25, 2012·Cardiovascular Research·Hoanglan NguyenBrett M Mitchell
Jan 24, 2014·Mediators of Inflammation·Ying-zhong LinQing-wei Ji
Mar 19, 2015·Cardiovascular Research·Wencai ZhangXiang Cheng
Apr 25, 2015·Cardiovascular Research·Soraya Taleb, Alain Tedgui
Mar 16, 2016·Cytokine & Growth Factor Reviews·Markus F Neurath, Susetta Finotto
Oct 22, 2016·Frontiers in Immunology·Miao YuXiang Cheng
Jun 24, 2017·Cell Communication and Signaling : CCS·Farhad SeifMohammadali Bahar
Aug 2, 2017·Disease Markers·Qingwei JiShaoping Nie
Aug 9, 2017·Hypertension·Tomasz J Guzik, Rhian M Touyz
May 17, 2018·British Journal of Pharmacology·Ulrich O WenzelHeimo Ehmke
Jun 9, 2018·Frontiers in Immunology·Shachi Pranjal Vyas, Ritobrata Goswami
Sep 28, 2018·Mediators of Inflammation·Jing YeYingzhong Lin

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
ELISA
PCR

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
Ritobrata Goswami, Mark H Kaplan
International Archives of Allergy and Immunology
Hans-Peter HauberQ Hamid
The Journal of Immunology : Official Journal of the American Association of Immunologists
P MonteyneJ P Coutelier
The Journal of Allergy and Clinical Immunology
Giorgio Ciprandi
© 2021 Meta ULC. All rights reserved