PMID: 8599429Jun 1, 1995Paper

Interleukin (IL)-1 alpha- and -1 beta-, IL-6-, and tumor necrosis factor-alpha-like immunoreactivities in human common and dysplastic nevocellular nevi and malignant melanoma

The American Journal of Dermatopathology
A A AhmedS Lidén

Abstract

Interleukin-1 alpha and -1 beta, interleukin-6, and tumor necrosis factor-alpha may have a protective effect against malignant transformation of melanocytes. By using monoclonal and polyclonal antisera we investigated, in paraformaldehyde-fixed tissue, the cellular distribution of these cytokines in human common and dysplastic nevocellular nevi and in malignant melanoma. Generally, the immunolabeling for all of these cytokines was both cytoplasmic and perinuclear as well as present in the basement membrane, which surrounds the individual cells or cellular nests of some of the nevi. In compound and intradermal nevi the immunolabeling was abundant, although there was a variation in the staining intensity between individual cells and even inside a single nevus cell, ranging from weak to strong. There was a strong labeling of the basement membrane around the cellular nests and around individual cells inside or outside the nests in the papillary and reticular dermis. With regard to the common junctional and dysplastic nevi and malignant melanoma, occasional immunolabeling could be seen in some cells within the cellular nests in the junctional area or papillary dermis, ranging from faint to moderate in intensity, but in this case the...Continue Reading

Citations

Oct 17, 2002·Dermatologic Clinics·Thomas G Salopek
Jun 13, 2017·Oncogene·W E Damsky, M Bosenberg
May 26, 2018·The Australasian Journal of Dermatology·Seohee Deanne ChoiWolfgang Weninger
Mar 30, 1999·International Journal of Cancer. Journal International Du Cancer·S MorettiM Herlyn

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