Interleukin (IL)-1 regulates ozone-enhanced tracheal smooth muscle responsiveness by increasing substance P (SP) production in intrinsic airway neurons of ferret.

Respiratory Physiology & Neurobiology
Z-X WuR D Dey

Abstract

Exposure to ozone induces airway hyperresponsiveness (AHR) mediated partly by substance P (SP) released from nerve terminals of intrinsic airway neurons. Our recent studies showed that interleukin (IL)-1, an important multifunctional proinflammatory cytokine, increases synthesis and release of SP from intrinsic airway neurons. The purpose of this study is to investigate the possible involvement of endogenous IL-1 in modulating neural responses associated with ozone-enhanced airway responsiveness. Ferrets were exposed to 2ppm ozone or filtered air for 3h. IL-1 in the bronchoalveolar lavage (BAL) fluid was significantly increased in ozone-exposed animals and responses of tracheal smooth muscle to methacholine (MCh) and electrical field stimulation (EFS) were elevated significantly. Both the SP nerve fiber density in tracheal smooth muscle and the number of SP-containing neurons in airway ganglia were significantly increased following ozone exposure. Pretreatment with IL-1 receptor antagonist (IL-1 Ra) significantly diminished ozone-enhanced airway responses to EFS as well as ozone-increased SP in the airway. To selectively investigate intrinsic airway neurons, segments of ferret trachea were maintained in culture conditions for 2...Continue Reading

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Citations

Jan 30, 2014·American Journal of Respiratory Cell and Molecular Biology·Gregory D ScottDavid B Jacoby
Feb 2, 2010·American Journal of Respiratory Cell and Molecular Biology·Dawn D HunterRichard D Dey
Dec 7, 2010·Immunologic Research·Mashael Al-HegelanJohn W Hollingsworth
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May 15, 2013·Free Radical Biology & Medicine·Hun LeeTae-Im Kim
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Feb 8, 2013·Toxicologic Pathology·Ann F HubbsRobert R Mercer
Apr 16, 2013·Reviews in the Neurosciences·Juan Carlos Martínez-LazcanoCarlos Paz
Mar 18, 2020·Frontiers in Endocrinology·Fu-Xing-Zi LiLing-Qing Yuan
Nov 4, 2010·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Hong SongXuchao Zhang

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