Interleukin (IL)-10 inhibits long-term IL-6 production but not preformed mediator release from rat peritoneal mast cells

The Journal of Clinical Investigation
J S MarshallM Jordana

Abstract

Mast cells have been implicated in a number of diseases involving chronic inflammation including asthma, rheumatoid arthritis, and inflammatory bowel diseases. They are a potent source of several cytokines, including IL-6 and TNF-alpha. Freshly isolated rat peritoneal mast cells will produce IL-6 in response to anti-IgE, LPS, PGE1, or PGE2; however, the mechanisms by which such cytokine production is regulated are poorly understood. IL-10 is recognized as an important immunoregulatory cytokine with effects on T cell development and the production of inflammatory cytokines. IL-10 has previously been described to enhance mast cell development in the context of IL-3 and IL-4. In the current study, we have examined the ability of IL-10 to modulate rat peritoneal mast cell IL-6 and TNF-alpha production in response to a variety of stimuli. We have observed that recombinant murine IL-10 can inhibit the production of both IL-6 and TNF-alpha by mast cells without altering the degree of histamine release in response to anti-IgE. Concentrations of IL-10 as low as 0.2 ng/ml were sufficient to inhibit IL-6 production by LPS- or anti-IgE-activated cells significantly. IL-10 also inhibited PGE1- and PGE2-induced IL-6 production. The relative ...Continue Reading

References

Jan 1, 1992·The Journal of Experimental Medicine·J S SilvaS G Reed
Dec 1, 1991·The Journal of Experimental Medicine·C BogdanC Nathan
Feb 1, 1991·The Journal of Experimental Medicine·L Thompson-SnipesD M Rennick
Aug 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·F P HeinzelR M Locksley
Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A Wodnar-Filipowicz, C Moroni
Jan 1, 1990·Annual Review of Immunology·J Van Snick
Mar 1, 1986·Journal of Clinical Pathology·I R SandersonJ A Walker-Smith
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Oct 1, 1987·European Journal of Immunology·L A AardenP M Lansdorp
Jul 1, 1993·The Journal of Clinical Investigation·H W GhalibS G Reed
Sep 1, 1993·European Journal of Immunology·J S MarshallJ Bienenstock
Apr 1, 1993·The Journal of Experimental Medicine·M HowardS Menon

❮ Previous
Next ❯

Citations

Nov 15, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M NiebuhrT Werfel
Jun 6, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M NiebuhrT Werfel
Jul 24, 2012·Seminars in Immunopathology·Rima Rachid, Dale T Umetsu
Mar 29, 2006·Current Allergy and Asthma Reports·Flurina MeilerMübeccel Akdis
Jan 29, 2011·Current Allergy and Asthma Reports·Marek Jutel, Cezmi A Akdis
Feb 5, 2003·Toxicon : Official Journal of the International Society on Toxinology·A C L NobreH S A Monteiro
May 23, 2001·International Immunopharmacology·N OsnaM M Khan
Mar 20, 2003·Immunology Letters·Pio ContiTheoharis C Theoharides
Jun 1, 1997·Immunology Today·M Pretolani, M Goldman
Jan 1, 1997·Research in Immunology·M Pretolani, M Goldman
Aug 5, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G R StentonA D Befus
Sep 21, 2001·Microbes and Infection·C A Akdis, K Blaser
Jun 20, 2000·Allergy·C A Akdis, K Blaser
Aug 1, 2009·Nature Reviews. Drug Discovery·Mübeccel Akdis, Cezmi A Akdis
Oct 2, 2004·Nature Reviews. Immunology·Jean S Marshall
Nov 18, 2000·British Journal of Pharmacology·T C TheoharidesA Athanasiou
Jun 20, 2001·Immunology·C A Akdis, K Blaser
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
Oct 28, 1999·American Journal of Respiratory Cell and Molecular Biology·M R StämpfliM Jordana
Jul 3, 1998·The Journal of Clinical Investigation·C A AkdisK Blaser
Jun 21, 2014·Cellular Immunology·Travis W FaberJohn J Ryan
Aug 8, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Michael G HaaseGustavo B Baretton
Oct 16, 2015·The Journal of Physiological Sciences : JPS·Sukanya PhungphongTepmanas Bupha-Intr
Jun 7, 2005·Expert Opinion on Biological Therapy·Johan VerhagenMübeccel Akdis
Jul 9, 2014·Mediators of Inflammation·Juandy JoElena Sandalova
Sep 10, 2010·The Science of the Total Environment·M BragaM Di Gioacchino
Aug 25, 2010·Biochemical and Biophysical Research Communications·Norika ChibaTetsuya Matsuguchi
Aug 25, 2009·Current Opinion in Immunology·Mübeccel Akdis
Feb 27, 2007·The Journal of Allergy and Clinical Immunology·Mübeccel Akdis, Cezmi A Akdis
May 17, 2006·Immunology and Allergy Clinics of North America·Johan VerhagenMübeccel Akdis
Jan 12, 2012·Microbiology and Immunology·Edyta BąbolewskaEwa Brzezińska-Błaszczyk
Nov 19, 2013·Journal of Gastroenterology and Hepatology·Takahiro HiratsukaSeigo Kitano
Jul 15, 2004·International Immunopharmacology·Randle M GallucciLaurence D Fechter
Nov 9, 2005·The Journal of Allergy and Clinical Immunology·Mübeccel AkdisCezmi A Akdis
Jun 9, 2001·Rheumatic Diseases Clinics of North America·L W Moreland
May 28, 2005·Microbes and Infection·Alison TaylorMübeccel Akdis
Jan 17, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Michail AlevizosTheoharis C Theoharides

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