Interleukins 2 and 12 produce significant recovery of cytotoxic function in dibutyltin-exposed human natural killer cells

Environmental Research
Margaret M WhalenBommanna G Loganathan

Abstract

Cytotoxic function of human natural killer (NK) cells is modulated by a variety of cytokines. Interleukins (IL) 2, 12, 15, and 18 and Interferon gamma (IFNgamma) are potent stimulators of NK cell cytotoxicity. Butyltins (BTs) are used in a variety of consumer products and industrial applications. Dibutyltin (DBT) is found in plastic products, beverages stored in PVC pipes during manufacturing, and poultry products. BTs appear to increase the risk of cancer and viral infections in exposed individuals. Recently, we have demonstrated that the ability of NK cells to kill tumor cells is greatly diminished after a 1-h exposure to dibutyltin. This inhibition of tumor killing function continues even after removal of the compound. There is no significant recovery of NK cytotoxic function even when the cells are allowed to recover for 6 days. In the current study we examine the effects of NK-stimulatory cytokines on the ability of NK cells to recover from the inhibitory effects of a 1-h DBT treatment. Highly purified NK cells (>95% CD16(+)) or a lymphocyte preparation containing both T lymphocytes and NK cells were treated with 5 microM DBT and then allowed to recover for 24 h, 48 h, 4 days, and 6 days in DBT-free medium containing eithe...Continue Reading

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Citations

Nov 1, 2005·Environmental Toxicology and Pharmacology·Reetta CatlinMargaret M Whalen
May 7, 2003·Chemico-biological Interactions·Margaret M WhalenTakao Saito
Jan 11, 2007·Human & Experimental Toxicology·T M Beach, M M Whalen
Nov 24, 2004·Human & Experimental Toxicology·Adrian ReedMargaret M Whalen
Jul 12, 2005·Environmental Toxicology·Thyneice R TaylorMargaret M Whalen

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