Interleukins and cancer immunotherapy

Immunotherapy
Takayuki YoshimotoJunichiro Mizuguchi

Abstract

Cancer is a complex disease with interactions between normal and neoplastic cells. Since current therapies for cancer largely rely on drugs or radiation that kill dividing cells or block cell division, these treatments may have severe side effects on normal proliferating cells in patients with cancer. Therefore, the potential for treatment of cancer patients by immunologic approaches, which may be specific for tumors and will not injure most normal cells, has great promise. Cancer immunotherapy aims to augment the weak host immune response to developing tumors. One strategy is to utilize cytokines such as IL-2. More recently, several exciting new interleukins have been characterized that have considerable promise for future immunotherapy. The promise of cancer immunotherapy largely depends upon the identification of these novel interleukins. This review provides an overview of the antitumor effects of relatively new interleukins as potential therapeutic agents applicable for cancer immunotherapy.

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Citations

May 11, 2011·Immunotherapy·Courtney Nicholas, Gregory B Lesinski
Jan 16, 2015·International Journal of Molecular Sciences·Doxakis AnestakisAthanasios Salifoglou
Jan 14, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Saiedeh Razi SoofiyaniBehzad Baradaran
Dec 21, 2019·Advanced Pharmaceutical Bulletin·Mansoureh MirabdollahiHojjat Sadeghi-Aliabadi
Jun 16, 2019·Cancer Communications·Jean-François RossiZhao-Yang Lu
May 10, 2020·Biological Research·Xiyi WeiLei Cai
Apr 10, 2021·Medical Oncology·Kyle P D'melloYujiang Fang
Oct 7, 2021·Journal of Cellular and Molecular Medicine·Adviti NaikJulie Decock

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