Interlocked DNA topologies for nanotechnology

Current Opinion in Biotechnology
Julián ValeroMichael Famulok

Abstract

Interlocked molecular architectures are well known in supramolecular chemistry and are widely used for various applications like sensors, molecular machines and logic gates. The use of DNA for constructing these interlocked structures has increased significantly within the current decade. Because of Watson-Crick base pairing rules, DNA is an excellent material for the self-assembly of well-defined interlocked nanoarchitectures. These DNA nanostructures exhibit sufficient stability, good solubility in aqueous media, biocompatibility, and can be easily combined with other biomolecules in bio-hybrid nano-assemblies. Therefore, the study of novel DNA-based interlocked systems is of interest for nanotechnology, synthetic biology, supramolecular chemistry, biotechnology, and for sensing purposes. Here we summarize recent developments and applications of interlocked supramolecular architectures made of DNA. Examples illustrating that these systems can be precisely controlled by switching on and off the molecular motion of its mechanically trapped components are discussed. Introducing different triggers into such systems creates molecular assemblies capable of performing logic gate operations and/or catalytic activity control. Interloc...Continue Reading

Citations

Dec 29, 2019·Angewandte Chemie·Qiancheng XiongChenxiang Lin
Jul 4, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Julián Valero, Marko Škugor
May 28, 2019·Chemical Communications : Chem Comm·Jatinder SinghKi-Whan Chi
Jul 28, 2020·Advanced Science·Yaqin HuYanfei Liu
Oct 1, 2020·Angewandte Chemie·Julián Valero, Michael Famulok
Mar 11, 2020·Journal of the American Chemical Society·Amanda Acevedo-JakeStephen M Goldup
Feb 5, 2019·Chemical Reviews·Friedrich C SimmelHari R Singh

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