Intermale aggression in corticotropin-releasing factor receptor 1 deficient mice.

Behavioural Brain Research
Stephen C Gammie, Sharon A Stevenson

Abstract

The anxiogenic neuropeptide, corticotropin-releasing factor (CRF), has a complex effect on intermale aggression. CRF receptor 1 (CRFR1) is the primary receptor for CRF and in this study, we examined in detail isolation-induced intermale aggression in CRFR1 deficient mice. All mice contained a mixed 50:50 inbred/outbred background to improve aggressive performance. Mice were isolated for 4 weeks prior to 2 consecutive days of aggression testing using the resident-intruder paradigm. Mice were also tested for anxiety on the elevated plus maze. Relative to littermate wild-type (WT) controls, CRFR1-mutant mice exhibited normal levels of intermale aggression over the 2 test days in terms of percentage showing aggression, number of attacks, time aggressive, and latency to first attack. In terms of sites of attacks on intruders, CRFR1-deficient mice attacked the ventral portion of the mid-section (including belly) significantly less frequently than WT males on test day 1, but these differences did not reach significance on test day 2. No other differences in sites of attacks were observed. Tail rattling also did not differ between groups. Importantly, KO males showed decreased anxiety relative to WT mice (consistent with previous repor...Continue Reading

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Citations

Mar 3, 2007·BMC Neuroscience·Stephen C GammieSharon A Stevenson
May 27, 2008·General and Comparative Endocrinology·Chun-Chun Chen, Russell D Fernald
Dec 15, 2007·CNS Drug Reviews·Catherine Borna FarrokhiJoachim Spiess
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Farhan MohammadAdam Claridge-Chang
Apr 25, 2017·Stress : the International Journal on the Biology of Stress·Kyle D KetchesinAudrey F Seasholtz
Jun 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Isabel M QuadrosKlaus A Miczek
Jun 14, 2017·Reviews in the Neurosciences·Robert Lalonde, Catherine Strazielle
Jul 30, 2020·Journal of Neuroscience Research·Alessandro Piccin, Angelo Contarino

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