Intermediate-advanced hepatocellular carcinoma in Argentina: Treatment and survival analysis

World Journal of Gastroenterology : WJG
Federico PiñeroMarcelo Silva

Abstract

Hepatocellular carcinoma (HCC) represents the sixteenth most frequent cancer in Argentina. The rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of HCC. To describe real-life treatments performed in patients with intermediate-advanced HCC before the approval of new systemic options. This longitudinal observational cohort study was conducted between 2009 and 2016 in 14 different regional hospitals from Argentina. Included subjects had intermediate-advanced Barcelona Clinic Liver Cancer (BCLC) HCC stages (BCLC B to D). Primary end point analyzed was survival, which was assessed for each BCLC stage from the date of treatment until last patient follow-up or death. Kaplan Meier survival curves and Cox regression analysis were performed, with hazard ratios (HR) calculations and 95% confidence intervals (95%CI). From 327 HCC patients, 41% were BCLC stage B, 20% stage C and 39% stage D. Corresponding median survival were 15 mo (IQR 5-26 mo), 5 mo (IQR 2-13 mo) and 3 mo (IQR 1-13 mo) (P < 0.0001), respectively. Among BCLC-B patients (n = 135), 57% received TACE with a median number of 2 sessions (IQR 1-3 sessions). Survival was significantly better in BCLC-B patients treated with T...Continue Reading

References

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Oct 13, 2018·World Journal of Gastroenterology : WJG·Federico PiñeroMarcelo Silva

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Citations

May 12, 2020·World Journal of Gastroenterology : WJG·Federico PiñeroMassimo Iavarone
Nov 21, 2020·Liver International : Official Journal of the International Association for the Study of the Liver·Claudia MaccaliFederico Piñero
Jun 23, 2021·Digestive Diseases and Sciences·Cecilia C GarciaAlejandra C Cherñavsky
Jul 10, 2021·World Journal of Gastroenterology : WJG·Federico Piñero, Leonardo Gomes da Fonseca
Aug 18, 2021·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Hong ZhaoJianqiang Cai

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Methods Mentioned

BETA
biopsy

Software Mentioned

STATA

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