Intermediate compartment (IC): from pre-Golgi vacuoles to a semi-autonomous membrane system

Histochemistry and Cell Biology
Jaakko Saraste, Michaël Marie

Abstract

Despite its discovery more than three decades ago and well-established role in protein sorting and trafficking in the early secretory pathway, the intermediate compartment (IC) has remained enigmatic. The prevailing view is that the IC evolved as a specialized organelle to mediate long-distance endoplasmic reticulum (ER)-Golgi communication in metazoan cells, but is lacking in other eukaryotes, such as plants and fungi. However, this distinction is difficult to reconcile with the high conservation of the core machineries that regulate early secretory trafficking from yeast to man. Also, it has remained unclear whether the pleiomorphic IC components-vacuoles, tubules and vesicles-represent transient transport carriers or building blocks of a permanent pre-Golgi organelle. Interestingly, recent studies have revealed that the IC maintains its compositional, structural and spatial properties throughout the cell cycle, supporting a model that combines the dynamic and stable aspects of the organelle. Moreover, the IC has been assigned novel functions, such as cell signaling, Golgi-independent trafficking and autophagy. The emerging permanent nature of the IC and its connections with the centrosome and the endocytic recycling system e...Continue Reading

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Citations

Oct 2, 2019·Frontiers in Cell and Developmental Biology·Peter M Luo, Michael Boyce
Jul 10, 2019·Annual Review of Cell and Developmental Biology·Matthew J Kennedy, Cyril Hanus
Sep 10, 2019·Frontiers in Cell and Developmental Biology·Jaakko Saraste, Kristian Prydz
Oct 1, 2018·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Feb 18, 2020·Frontiers in Cell and Developmental Biology·Kristian PrydzJaakko Saraste
Aug 10, 2019·Frontiers in Cell and Developmental Biology·Fabiola MascanzoniAntonino Colanzi
Nov 27, 2020·Scientific Reports·Clara-Marie GürthElisa D'Este
Dec 6, 2020·Histochemistry and Cell Biology·Douglas J Taatjes, Jürgen Roth
Dec 29, 2020·Frontiers in Plant Science·Yoko Ito, Yohann Boutté
Jun 6, 2021·The FEBS Journal·Nils BäckBetty A Eipper

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Datasets Mentioned

BETA
GM130

Methods Mentioned

BETA
confocal microscopy
phosphotransferase
dissection
GTPases
nucleotide exchange
GTPase
protein folding

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