Intermediate-dose intravenous methotrexate with intravenous mercaptopurine is superior to repetitive low-dose oral methotrexate with intravenous mercaptopurine for children with lower-risk B-lineage acute lymphoblastic leukemia: a Pediatric Oncology Group phase III trial

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
D H MahoneyBruce Camitta

Abstract

To determine whether early intensification with 12 courses of intravenous methotrexate and intravenous mercaptopurine (IVMTX/IVMP) is superior to 12 courses of repetitive, low-dose oral MTX with I.V. MP (LDMTX/IVMP) for prevention of relapse in children with lower-risk B-lineage acute lymphoblastic leukemia (ALL). Seven hundred nine patients were entered onto the study. Vincristine, prednisone, and asparaginase were used for remission induction. Patients were randomized to receive intensification with either IVMTX 1,000 mg/m2 plus IVMP 1,000 mg/m2 (regimen A) or LDMTX 30 mg/m2 every 6 hours for six doses with IVMP 1,000 mg/m2 (regimen B). Twelve courses were administered at 2-week intervals. Triple intrathecal therapy (TIT) was used for CNS prophylaxis. Continuation therapy included standard oral MP, weekly MTX, and TIT every 12 weeks for 2 years. Six hundred ninety-nine (99%) patients achieved remission. Three hundred forty-nine were assigned to regimen A and 350 to regimen B. The estimated 4-year continuous complete remission (CCR) rate for patients treated with regimen A is 80.3% (SE = 2.9%) and with regimen B is 75.9% (SE = 3.1%). By log-rank analysis, regimen A demonstrated superior CCR (P = .013). Transient neutropenia/th...Continue Reading

Citations

Feb 25, 2000·Current Opinion in Oncology·C H Pui
May 8, 2000·Medical and Pediatric Oncology·A M LeaheyB J Lange
May 2, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M ClarkeUNKNOWN Childhood ALL Collaborative Group
Jul 12, 2005·Pediatric Blood & Cancer·Stuart S WinterMichael D Amylon
Nov 9, 2005·Pediatric Blood & Cancer·Donald H MahoneyMeenakshi Devidas
Jul 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julio C BarredoA Kim Ritchey
Sep 5, 2007·Cancer Chemotherapy and Pharmacology·Peter D ColeBarton A Kamen
Sep 7, 2007·Journal of Pediatric Hematology/oncology·Barton A Kamen
Aug 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barton A KamenW Archie Bleyer
Aug 27, 1998·The New England Journal of Medicine·C H Pui, W E Evans
Feb 2, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KantarjianE J Freireich
Sep 17, 2013·Pediatric Blood & Cancer·Ian Joseph Cohen, Johannes E Wolff
Dec 29, 2000·Pediatric Hematology and Oncology·O M FuskevågJ Aarbakke
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D H MahoneyB Camitta
Oct 12, 2001·International Journal of Hematology·J HaraUNKNOWN Osaka Childhood Leukemia Study Group
Sep 12, 2012·Nature Reviews. Neurology·Laetitia PadovaniXavier Muracciole
Oct 19, 2000·Journal of Pediatric Hematology/oncology·P S Gaynon
Aug 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B A KamenE Glatstein
Oct 25, 2006·Mental Retardation and Developmental Disabilities Research Reviews·Peter D Cole, Barton A Kamen
Apr 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P S GaynonH N Sather
Dec 29, 2000·Pediatric Hematology and Oncology·P D Cole, B A Kamen
Nov 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter D ColeBarton A Kamen
Oct 12, 1999·Journal of Chromatography. B, Biomedical Sciences and Applications·Y SuM V Relling

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Bruce CamittaD Strother
© 2021 Meta ULC. All rights reserved