Intermediate dose metoclopramide is not more effective than standard dose metoclopramide for patients who present to the emergency department with nausea and vomiting: a pilot study

Emergency Medicine Australasia : EMA
Swee ChamAnne-Maree Kelly

Abstract

To determine whether intermediate dose metoclopramide is more effective than standard dose metoclopramide for patients who present to the ED with nausea and vomiting. This prospective, single-blind, randomized trial was conducted in the ED of two community teaching hospitals in a convenience sample of adult patients who presented to ED with nausea and vomiting. Patients were randomized to receive either 10 mg metoclopramide IV or 0.4 mg/kg IV (up to a maximum dose of 32 mg). The outcomes measured were: change in nausea score (measured on a 11-point verbal rating scale), requirement for other anti-emetic drug administration, and presence of side-effects. Fifty-eight patients were eligible for analysis (34 in 10 mg group and 24 in 0.4 mg/kg group). Median reduction in nausea score in 10 mg group was four (range 0-10, 95% CI 3-5) compared with five for 0.4 mg/kg group (range -1-10, 95% CI 4-6). This difference was not statistically significant (P = 0.629). Five patients in the 10 mg group required rescue anti-emetic, compared with three in the 0.4 mg/kg group (P = 1.00). There were no side-effects in the 10 mg group and two in the 0.4 mg/kg group. This study suggests that there is no difference in effectiveness between 10 mg and 0...Continue Reading

References

Feb 1, 1990·Canadian Journal of Physiology and Pharmacology·G J Sanger
Feb 4, 1984·Lancet·S G AllanJ F Smyth
Oct 14, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P S LoewenP J Zed
Apr 3, 2003·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Polly E BijurE John Gallagher

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Citations

Dec 22, 2009·The Journal of Emergency Medicine·Asad E PatanwalaPeter Rosen
May 23, 2015·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Robert MeekGeorge Braitberg
Jan 8, 2010·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Robert MeekXue Feng Hu
Sep 29, 2015·The Cochrane Database of Systematic Reviews·Jeremy S FurykDiana Egerton-Warburton
Jan 12, 2019·The British Journal of Radiology·Ali B AlhailiyMark McEntee
Sep 25, 2017·Emergency Medicine Australasia : EMA·Robert MeekShane Anthony

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