Intermediate filament expression by normal and diseased human corneal epithelium

Human Pathology
M J ElderJ K Dart

Abstract

Cicatricial conjunctivitis may be a sequel to systemic disorders (eg, Stevens-Johnson syndrome, cicatricial pemphigoid) or local disorders such as chemical burns. The cicatrisation is often associated with corneal epithelial changes that cause visual loss. These have been attributed to encroachment of the conjunctival epithelium over the cornea. However, the epithelial anomalies are poorly understood. We investigated the corneal epithelial changes in cicatricial conjunctivitis with an immunohistochemical study of intermediate filaments in normal and pathological specimens. Our results show that the normal corneal epithelium is immunoreactive for cytokeratin 3 (CK 3) but not cytokeratin 19 (CK 19), whereas normal conjunctival epithelium is CK 3 negative and CK 19 positive. Conjunctiva artificially transposed over the cornea (after therapeutic conjunctival flap reconstruction) retained the normal pattern of conjunctival cytokeratin expression (CK 3 negative, CK 19 positive). Conversely, the entire corneal epithelium exhibited the normal cytokeratin pattern (CK 3 positive, CK 19 negative) in 82% of Stevens-Johnson, 80% of cicatricial pemphigoid, and 69% of chemical burns specimens. The findings suggest that conjunctival encroachme...Continue Reading

References

Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·P StosiekR Moll
Nov 1, 1991·The Journal of Investigative Dermatology·A C MarkeyI M Leigh
Mar 22, 1991·The Journal of Comparative Neurology·S L Semple-Rowland
Jan 1, 1985·Annals of the New York Academy of Sciences·E B LaneI M Leigh
Aug 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H Battifora, M Kopinski
Jan 1, 1989·Acta Ophthalmologica. Supplement·R A Thoft
Jun 1, 1985·Ophthalmology·S C TsengK R Kenyon
Nov 1, 1982·The Journal of Cell Biology·J Woodcock-MitchellT T Sun
Mar 1, 1983·American Journal of Ophthalmology·A Sommer

❮ Previous
Next ❯

Citations

Apr 21, 2017·Current Opinion in Ophthalmology·Kyeong Hwan Kim, Shahzad I Mian
Aug 6, 2005·Experimental Eye Research·Kazunari HigaKazuo Tsubota
Aug 13, 2008·Current Eye Research·Stephanie L WatsonJulie T Daniels
Mar 22, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Marta SacchettiStefano Bonini
Nov 25, 2003·Eye·S BoniniA Lambiase
Aug 31, 2019·Scientific Reports·Rabab SharifDimitrios Karamichos
Jul 29, 2003·Cornea·Pietro Maria DonisiDiego Ponzin
Jan 6, 2000·Current Opinion in Ophthalmology·A LambiaseS Bonini
Apr 15, 2019·Experimental Eye Research·Surabhi SonamJonathan J Henry
Jun 14, 2002·Progress in Retinal and Eye Research·Susanne Pitz, Roland Moll

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.