PMID: 7538772Feb 1, 1995Paper

Intermediate filaments in disease

Current Opinion in Cell Biology
W H McLean, E B Lane

Abstract

Intermediate filaments are major structural proteins encoded by a large multigene family. Their tissue-specific expression makes them important in studies of development, differentiation and pathology. Most intermediate filaments are keratins; recent discoveries of keratin mutations in a range of genetic skin disorders have clarified their role as providing essential structural support for cells in different physical settings.

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