PMID: 7035618Mar 1, 1982Paper

Intermediate filaments of Schwann cells

Journal of Neurochemistry
L Autilio-GambettiP Gambetti

Abstract

Intermediate filaments were prepared from distal stumps of rabbit sciatic nerve 5 weeks after nerve section, at which time Schwann cells account for 85--90% of the cell area. A polypeptide of molecular weight 58,000 was the main component of this fraction. An antiserum raised in guinea pig against this polypeptide stained all cells present in the distal stump, as well as Schwann cells and 3T3 cells in culture. The identity of the molecular weight 58,000 polypeptide obtained from distal stumps with vimentin was proved with one and two-dimensional sodium dodecyl sulfate polyacrylamide gel electrophoresis and with immunoautoradiography. It is concluded that the intermediate filament subunit of undifferentiated Schwann cells is vimentin. The possibility that Schwann cells in normal nerve may have another type of intermediate filament besides vimentin cannot be ruled out.

References

Jan 1, 1978·Differentiation; Research in Biological Diversity·G S BennettH Holtzer
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D L GardE Lazarides
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·W W FrankeK Weber
Apr 6, 1979·Brain Research·P S SpencerV Zabrenetzky
Oct 1, 1978·The Journal of Cell Biology·W S AdairU W Goodenough
Oct 1, 1978·Journal of Neurocytology·H J Weinberg, P S Spencer
Feb 10, 1976·Biochemistry·G F Ames, K Nikaido
Oct 1, 1976·Journal of the Neurological Sciences·M J BrownA K Asbury
Dec 1, 1976·Analytical Biochemistry·S P MahadikM M Rapport
Dec 1, 1980·Journal of Neurochemistry·G Shecket, R J Lasek
Nov 1, 1981·Journal of Neurochemistry·L Autilio-GambettiP Gambetti
Feb 1, 1981·Experimental Cell Research·M Dubois-DalcqB W Burge

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Citations

Jan 1, 1985·Cell and Tissue Research·P BałukS Matsuda
Aug 1, 1984·Journal of Neurocytology·S S Scherer, S S Easter
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·P LoddingG Stenman
Mar 1, 1984·Developmental Biology·P BovolentaC A Mason
Apr 1, 1991·Journal of the Neurological Sciences·G L MancardiD Zaccheo
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S MonacoP Gambetti
Jul 1, 1992·The Journal of Cell Biology·B M KellyP J Brophy
Oct 13, 2001·Journal of Neuroscience Research·S M NicholsonR Bruzzone
May 30, 2008·Muscle & Nerve·Francesca NotturnoAntonino Uncini
Jan 20, 1992·Brain Research·D BianchiniG L Mancardi
Jun 18, 2009·Muscle & Nerve·Francesca NotturnoAntonino Uncini

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