Intermediate frequency magnetic field at 23 kHz does not modify gene expression in human fetus-derived astroglia cells

Bioelectromagnetics
Tomonori SakuraiJunji Miyakoshi

Abstract

The increased use of induction heating (IH) cooktops in Japan and Europe has raised public concern on potential health effects of the magnetic fields generated by IH cooktops. In this study, we evaluated the effects of intermediate frequency (IF) magnetic fields generated by IH cooktops on gene expression profiles. Human fetus-derived astroglia cells were exposed to magnetic fields at 23 kHz and 100 µT(rms) for 2, 4, and 6 h and gene expression profiles in cells were assessed using cDNA microarray. There were no detectable effects of the IF magnetic fields at 23 kHz on the gene expression profile, whereas the heat treatment at 43 °C for 2 h, as a positive control, affected gene expression including inducing heat shock proteins. Principal component analysis and hierarchical analysis showed that the gene profiles of IF-exposed groups were similar to the sham-exposed group and were different than the heat treatment group. These results demonstrated that exposure of human fetus-derived astroglia cells to an IF magnetic field at 23 kHz and 100 µT(rms) for up to 6 h did not induce detectable changes in gene expression profile.

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Citations

Jun 1, 2013·Journal of Radiation Research·Tomonori SakuraiJunji Miyakoshi
Sep 19, 2014·International Journal of Environmental Research and Public Health·Shin KoyamaJunji Miyakoshi
Oct 15, 2013·Bioelectromagnetics·Kohei MizunoJunji Miyakoshi
Jun 6, 2014·International Journal of Radiation Biology·Akira UshiyamaChiyoji Ohkubo
May 27, 2020·Bioelectromagnetics·Mohsen KoohestaniMaxim Zhadobov
May 28, 2019·International Journal of Environmental Research and Public Health·Shin OhtaniKazuyuki Ishii
Mar 9, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Shin OhtaniKenji Hattori

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