Intermediate hyperglycaemia to predict progression to type 2 diabetes (ELSA-Brasil): an occupational cohort study in Brazil

The Lancet. Diabetes & Endocrinology
Maria Inês SchmidtBruce Bartholow Duncan

Abstract

The burden of diabetes is increasing worldwide and diabetes can be prevented with intervention in people with impaired glucose tolerance (IGT). Intermediate hyperglycaemia defined without an oral glucose tolerance test as impaired fasting glucose (IFG) and high HbA1c are also used to characterise risk. We aimed to assess the prognostic properties of five definitions of intermediate hyperglycaemia (also known as prediabetes) on the basis of their ability to predict who will progress to diabetes. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is an occupational cohort study of active or retired civil servants, aged 35-74 years, recruited from public universities and research institutes in six state capital cities in Brazil. We excluded participants who provided insufficient information to ascertain diabetes status, those without information on relevant covariates, and those with diabetes. We classified type 2 diabetes on the basis of self-report, medication use, measures of fasting plasma glucose (FPG), 2 h plasma glucose, and HbA1c. We used five laboratory definitions of intermediate hyperglycaemia: IGT (2 h plasma glucose ≥7·8 mmol/L [≥140 mg/dL]); IFG based on American Diabetes Association (ADA) criteria (FPG ≥...Continue Reading

Citations

Mar 18, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·M Lazo-PorrasA Bernabé-Ortiz
Oct 1, 2020·Population Health Metrics·Bruce Bartholow DuncanMaria Inês Schmidt
May 30, 2020·Nutrients·Miquel Bennasar-VenyAina M Yañez
Sep 17, 2020·Diabetes Care·Mayer B Davidson
Jan 14, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ana Paula Borges SantosPaulo Caramelli
Feb 9, 2021·JAMA Internal Medicine·Mary R RooneyElizabeth Selvin
Feb 20, 2021·Ciência & saúde coletiva·Betine Pinto Moehlecke IserMaria Inês Schmidt
Dec 14, 2019·Atherosclerosis·Stéphane Ramin-MangataBertrand Cariou
Jun 5, 2021·Journal of the American College of Cardiology·Raul D SantosChristie M Ballantyne
Aug 18, 2021·Endocrinology and Metabolism Clinics of North America·Stephen Colagiuri
Sep 3, 2021·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Alex J F CassenoteAluisio C Segurado

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