Intermediate stage hepatocellular carcinoma: a summary review

Journal of Hepatocellular Carcinoma
Omar ElshaarawyImam Waked

Abstract

It is well known that intermediate stage hepatocellular carcinoma (HCC) encompasses the widest class of patients with this disease. The main characteristic of this special sub-group of patients is that it is extensively heterogenous. This substantial heterogeneity is due to the wide range of liver functions of such patients and variable tumor numbers and sizes. Real world clinical data show huge support for transarterial chemo-embolization (TACE) as a therapeutic modality for intermediate stage HCC, applied in 50%-60% of those class of patients. There are special considerations in various international guidelines regarding treatment allocation in intermediate stage HCC. There is an epidemiological difference in HCC in eastern and western cohorts, and various guidelines have been proposed. In patients with HCC, it has frequently been reported that there is poor correlation between the clinical benefit and real gain in patient condition and the conventional way of tumor response assessment after locoregional treatments. This is due to the evaluation criteria in addition to the scoring systems used for treatment allocation in those patients. It became clear that intermediate stage HCC patients receiving TACE need a proper prognost...Continue Reading

Citations

Sep 22, 2020·World Journal of Gastroenterology : WJG·Ayman Bannaga, Ramesh P Arasaradnam
Jul 2, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Wei-Shuo ZhangHua-Yuan Yang
Jun 8, 2021·World Journal of Gastroenterology : WJG·Liang-Cheng ChenMoon-Sing Lee

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BETA
surgical resection

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mRECIST
TARE

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