Intermediate-term outcomes with expanded criteria deceased donors in kidney transplantation: a spectrum or specter of quality?

Annals of Surgery
Robert J StrattaPatricia L Adams

Abstract

To compare intermediate-term outcomes in adult recipients of expanded criteria (ECD) versus concurrent standard criteria (SCD) deceased donor kidney transplants at a single center using a standardized approach. Expanded criteria donors (ECDs) are a source of kidneys that increase the donor organ pool, but the value of transplanting these kidneys has been questioned because of concerns regarding diminished survival and predicted poorer intermediate-term outcomes. Over a 47-month period, we performed 244 deceased donor kidney transplants into adult recipients, including 143 from SCDs and 101 from ECDs. Management algorithms were implemented to preserve nephron function, and recipient selection for an ECD kidney transplant was based on low immunologic risk. All patients received depleting antibody induction in combination with tacrolimus and mycophenolate mofetil. A total of 188 patients (77%) had at least a 1-year follow-up. ECDs were older, had a higher BMI, had an increased incidence of cerebrovascular brain death and preexisting donor hypertension, and had a lower estimated creatinine clearance (CrCl, all P < 0.01) compared with SCDs. Cold ischemic times were similar between groups, but more ECD kidneys were preserved with pul...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Apr 1, 1996·Surgery·L E RatnerJ S Bender
Feb 22, 2001·Journal of the American Society of Nephrology : JASN·Akinlolu O OjoFriedrich K Port
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Howard M NathanAkinlolu O Ojo
Apr 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Robert A MetzgerRobert M Merion
Jun 28, 2003·Transplantation·Mark A SchnitzlerZoltan Kalo
Jun 28, 2003·Transplantation·Christopher J SonnendayRobert A Montgomery
Jan 11, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Allan J CollinsUNKNOWN United States Renal Data System
Mar 12, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jesse D ScholdHerwig-Ulf Meier-Kriesche
Mar 24, 2005·The New England Journal of Medicine·James W WilliamsMichelle A Josephson
May 10, 2005·Clinical Transplantation·Edwina S Baskin-BeyScott L Nyberg
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Uwe PögeRainer P Woitas
May 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Vikas R DharnidharkaRichard J Howard
Jun 10, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Herwig-Ulf Meier-KriescheBruce Kaplan
Oct 6, 2005·JAMA : the Journal of the American Medical Association·Robert A MontgomeryDaniel S Warren
Mar 21, 2006·Surgery·Robert J StrattaPatricia L Adams

❮ Previous
Next ❯

Citations

Feb 1, 2012·World Journal of Urology·Javier BarbaIgnacio Pascual
Nov 8, 2008·International Urology and Nephrology·Ramesh SaxenaXin J Zhou
Apr 15, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sri G YarlagaddaChirag R Parikh
Dec 24, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sri G YarlagaddaChirag R Parikh
Jun 16, 2010·Transplantation·Suverta BhayanaKanae Ishihara
Jul 31, 2007·Drugs·Nicole A Weimert, Rita R Alloway
Jun 24, 2008·Drugs·Andrew A HousePatrick P Luke
Jun 2, 2012·Clinical Journal of the American Society of Nephrology : CJASN·Joshua D MezrichAnthony M D'Alessandro
Mar 5, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Connie J WangJames B Wetmore
Feb 9, 2012·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Faissal Abdulraheem ShaheenAbdulla Al Sayyari
Oct 17, 2013·Current Medical Research and Opinion·J Smith-PalmerW Valentine
Feb 12, 2013·Journal of the American College of Surgeons·Alan C FarneyRobert J Stratta
Jan 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R MateoY Genyk
May 26, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J E LockeR A Montgomery
Oct 28, 2009·Transplantation Proceedings·P DomagalaA Chmura
Aug 30, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Julio PascualJohn D Pirsch
Jul 11, 2012·Scandinavian Journal of Urology·Javier BarbaIgnacio Pascual
Dec 19, 2006·Transplantation Proceedings·S M GreensteinV Tellis
May 8, 2007·Journal of the American College of Surgeons·Robert J StrattaPatricia L Adams
Dec 30, 2017·Clinical Transplantation·Giuseppe OrlandoRobert J Stratta
Mar 25, 2016·World Journal of Transplantation·Vassilis Filiopoulos, John N Boletis
Mar 25, 2016·World Journal of Transplantation·Yousef Al-ShraidehRobert J Stratta
May 10, 2018·Clinical Transplantation·Muhammad A KhanRobert J Stratta
Sep 13, 2008·Clinical Transplantation·A Reeves-DanielE L Hartmann
Oct 9, 2009·Current Opinion in Organ Transplantation·Jason RheeRichard Freeman
Jul 20, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B EkserP Rigotti
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M G J SnoeijsL W E van Heurn
Jan 29, 2013·Clinical Transplantation·Rebecca A SnyderDerek E Moore
Jun 21, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Elisa Sefora PierobonRigotti Paolo
Jun 18, 2017·Frontiers in Bioengineering and Biotechnology·Afrânio Côgo DestefaniBreno Valentim Nogueira
Jul 7, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Alexandra Nicolau FerreiraHelio Tedesco-Silva Junior
Sep 25, 2014·Clinical Transplantation·Yousef Al-ShraidehRobert J Stratta
Feb 27, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Sara KamranGwenaëlle Vidal-Trecan
Mar 12, 2010·British Journal of Hospital Medicine·Kelda SheridanNiaz Ahmad
Aug 12, 2014·Clinical Transplantation·E Lledó-GarcíaJ Pascual
Jul 29, 2017·International Scholarly Research Notices·Muhammad Abdul Mabood KhalilRabeea Azmat

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.