Intermediate thyroid carcinoma in humans and ultimobranchial tumors in bulls: A comparative morphological and immunohistochemical study

Endocrine Pathology
O Ljungberg, Per Olle Nilson

Abstract

The intermediate type of thyroid carcinoma in humans has been defined as having characteristics of both follicular and parafollicular cell carcinoma. The ultimobranchial (UB) body in mammals is believed to harbor stem cells capable of developing both follicular and parafollicular cells. Hyperplastic and neoplastic lesions of the UB remnants and of the parafollicular cell system frequently occur in bulls. Such lesions, found in 64 individuals (6%) derived from an autopsy material of 1,101 bulls, have been compared structurally and immunohistochemically with 18 human cases of thyroid carcinoma of the intermediate type, in order to define their possible biological relationship. UB changes in bulls formed a continuum ranging from hyperplastic nodules to gross tumors. They contained all epithelial components present in the normal UB remnants in cattle: UB cysts and tubules and solid nests of small basophilic immature cells, which were immunocytochemically indifferent, as wellas mature follicular and neuroendocrine cells. The indifferent cell component dominated in most bull tumors; a minority were mainly formed by mature follicular or parafollicular cells. Human tumors resembled the bull UB tumors structurally and immunohistochemica...Continue Reading

References

Apr 1, 1987·The Australian and New Zealand Journal of Surgery·G F Adkins, L Hartley
Apr 1, 1987·Scottish Medical Journal·A D BurtM K Browne
Jan 1, 1986·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·N KimuraT Namiki
Oct 1, 1973·The Journal of Clinical Endocrinology and Metabolism·V A LiVolsiA H Tashjian
Jul 1, 1970·Archivum Histologicum Japonicum = Nihon Soshikigaku Kiroku·Y Kameda
Feb 1, 1969·The American Journal of Clinical Nutrition·L KrookK McEntee
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Feb 1, 1984·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J L CordellD Y Mason
Jan 1, 1983·Virchows Archiv. A, Pathological Anatomy and Histopathology·M PfaltzJ P Mühlethaler
Jul 1, 1984·Medical Hypotheses·O Ljungberg

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.