Intermedin/adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice

International Journal of Obesity : Journal of the International Association for the Study of Obesity
H ZhangX Wang

Abstract

There is an urgent need to develop interventions and policies to mitigate the health effects of obesity by targeting its metabolic mediators. Adrenomedullin 2 (AM2)/intermedin (IMD) is a secreted peptide that has an important role in protecting the cardiovascular system. However, the role of AM2 in type 2 diabetes is unknown. Wild-type (WT) and aP2/AM2 transgenic (aAM2-tg) mice were fed a high-fat diet (HFD) for 8 weeks, and WT mice were treated with AM2 through mini-osmotic pumps. Indirect calorimetry, ambulatory activity and food intake, hyperinsulinemic-euglycemic clamp test, glucose and insulin tolerance tests were used for assessing insulin resistance. Rat primary adipocytes and pre-adipocyte-derived adipocytes were used for in vitro experiments. Real-time PCR and western blot were used for analyses of gene expression and protein level. AM2 and receptor activity-modifying proteins expressions were significantly decreased in the adipose tissue of obese mice. AM2 treatment significantly reduced blood glucose, fasting serum insulin and free fatty acid levels, improved glucose tolerance and insulin sensitivity, and increased the glucose infusion rate during a hyperinsulinemic-euglycemic clamp test, indicating ameliorated HFD-i...Continue Reading

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Citations

Apr 14, 2017·British Journal of Pharmacology·Song-Yang ZhangXian Wang
Jan 21, 2017·BioMed Research International·Umesh D WankhadeKeshari M Thakali
Oct 24, 2019·The Journal of Clinical Endocrinology and Metabolism·Jimin KimYoonseok Heo
Jan 3, 2020·Critical Reviews in Clinical Laboratory Sciences·Solaleh EmamgholipourReza Meshkani
Aug 28, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Allison E McQueenJen-Chywan Wang
Dec 7, 2018·Journal of Physiology and Biochemistry·A Kaisanlahti, T Glumoff
Aug 28, 2021·International Journal of Molecular Sciences·Shindy Soedono, Kae Won Cho

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