PMID: 9189744May 1, 1997Paper

Intermethod variability of sodium and potassium results: patients' sera and commercially available control sera

European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
Giampaolo CattozzoC Franzini

Abstract

Sodium and potassium were measured in sets of 102 to 107 patients sera, and in 31 commercially available control sera. The results from four routine analytical methods/systems (indirect potentiometry: two; direct potentiometry and enzymatic assay: one each) were compared with those from a flame photometry-based reference method. In the assay of patient sera, substantial agreement was observed in some comparisons, clinically relevant bias in others. The inter-assay changes observed for the control sera differed significantly from those shown by the patients sera (i.e. commercial control sera were non-commutable) in about 12% of the comparisons, as a whole. Recalculation of serum sample results with a single control serum as calibrator lowered or increased the bias originally present according to whether the serum itself was commutable or not. Moreover, the inter-method variability in the assay of commercial control sera was lower with commutable sera, higher with non-commutable sera. With the exception of liquid sera stabilized with ethylene glycol, there was no evident link between any specific characteristic of the commercial control sera (matrix and physical state) and their degree of commutability.

References

May 2, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·W C van HeldenJ H Souverijn
Jan 1, 1989·Critical Reviews in Clinical Laboratory Sciences·C G Fraser, E K Harris
Feb 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·A UldallS Bak

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Citations

Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·G CattozzoG V d'Eril
Mar 25, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·C RicósC Perich
Sep 19, 1998·Clinical Biochemistry·C Franzini, F Ceriotti

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