PMID: 7538246May 1, 1995Paper

Intermittent androgen suppression in the treatment of prostate cancer: a preliminary report

Urology
S Larry GoldenbergKoichiro Akakura

Abstract

To test the feasibility of using intermittent androgen suppression in the treatment of prostate cancer by taking advantage of the reversible action of medical castration. Observations were made on a group of 47 patients (clinical Stage D2, 14; D1, 10; C, 19; B2, 2; and A2, 2) with a mean follow-up time of 125 weeks. Treatment was initiated with combined androgen blockade and continued for at least 6 months until a serum prostate-specific antigen (PSA) nadir was observed. Medication was then withheld until the serum PSA increased to a mean value between 10 and 20 ng/mL. This cycle of treatment and no treatment was repeated until the regulation of serum PSA became androgen independent. The first two treatment cycles lasted 73 and 75 weeks, with a mean time off therapy of 30 and 33 weeks and an overall mean percentage time off therapy of 41% and 45%, respectively. The mean time to achieve a nadir level of serum PSA was 20 weeks in cycle 1 and 18 weeks in cycle 2. Serum testosterone returned to the normal range within 8 weeks (range, 1 to 26) of stopping treatment. The off-treatment period in both cycles was associated with an improvement in sense of well-being and the recovery of libido and potency in the men who reported normal o...Continue Reading

Citations

Nov 20, 1997·The Prostate·I M ThompsonJ Crowley
Jul 27, 1999·The Prostate·N J HegartyD S Coffey
Jan 5, 2000·Seminars in Surgical Oncology·L J Denis, K Griffiths
Jul 10, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·U G Mueller-LisseJ Kurhanewicz
Feb 28, 2009·World Journal of Urology·Dominique PrapotnichGuy Vallancien
Oct 24, 2008·International Journal of Clinical Oncology·Hiroyoshi SuzukiTomohiko Ichikawa
Feb 9, 2000·Der Urologe. Ausg. A·U W TunnR Kurek
Jun 27, 2002·Current Urology Reports·C R Pound, A W Partin
Sep 17, 2002·Urology·Antonio Hurtado-CollLaurence Klotz
Feb 1, 2003·Urology·Endre Z Neulander, Mark S Soloway
Mar 1, 1997·Urology·P R CarrollM Roach
Dec 4, 1998·Urology·R Kirby
Jul 1, 1995·Trends in Biotechnology·R W Jack, H G Sahl
Feb 26, 2003·European Urology·Dominique PrapotnichGuy Vallancien
Jan 15, 1997·International Journal of Radiation Oncology, Biology, Physics·A L Zietman, W U Shipley
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N A Dawson, D G McLeod
Apr 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M Galbraith, G M Duchesne
Aug 23, 2002·Critical Reviews in Oncology/hematology·Theo M de Reijke, Laurence Collette
Jun 20, 2002·Clinical Endocrinology·Shehzad BasariaAdrian S Dobs
Feb 19, 1998·British Journal of Urology·A HorwichD P Dearnaley
Apr 26, 2000·BJU International·J M Fitzpatrick
Apr 5, 2013·The New England Journal of Medicine·Maha HussainIan M Thompson
Nov 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Harsh Vardhan JainAvner Friedman
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y UmekitaS Liao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.