PMID: 9647058Jul 1, 1998Paper

Intermittent antegrade tepid versus cold blood cardioplegia in elective myocardial revascularization

The Annals of Thoracic Surgery
A C FioreH B Barner

Abstract

The ideal temperature for blood cardioplegia administration remains controversial. Fifty-two patients who required elective myocardial revascularization were prospectively randomized to receive intermittent antegrade tepid (29 degrees C; group T, 25 patients) or cold (4 degrees C; group C, 27 patients) blood cardioplegia. The two cohorts were similar with respect to all preoperative and intraoperative variables. The mean septal temperature was higher in group T (T, 29.6 degrees +/- 1.1 degrees C versus 17.5 degrees +/- 3.0 degrees C; p < 0.0001). After reperfusion, group T exhibited significantly greater lactate and acid release despite similar levels of oxygen extraction (p < 0.05). The creatine kinase-MB isoenzyme release was significantly lower in group T (764 +/- 89 versus 1,120 +/- 141 U x h/L; p < 0.04). Hearts protected with tepid cardioplegia demonstrated significantly increased ejection fraction with volume loading, improvement in left ventricular function at 12 hours, and decreased need for postoperative inotropic support (p < 0.05). The frequency of ventricular defibrillation after cross-clamp removal was lower in this cohort (p < 0.05). There were no hospital deaths, and both groups had similar postoperative courses...Continue Reading

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Citations

May 1, 2007·The Journal of Thoracic and Cardiovascular Surgery·Kathryn L SlootsGeoffrey P Dobson
Mar 20, 2003·The Annals of Thoracic Surgery·Pierre-Emmanuel FalcozJoseph-Philippe Etievent
Mar 1, 2000·The Journal of Thoracic and Cardiovascular Surgery·S ChocronJ P Etievent
Jul 25, 2003·Asian Cardiovascular & Thoracic Annals·Teing Ee TanHugh S Paterson
May 2, 2001·The Cochrane Database of Systematic Reviews·K ReesS Ebrahim

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