PMID: 8966498Jan 1, 1996Paper

Intermittent cyclic therapy with etidronate prevents corticosteroid-induced bone loss: two years of follow-up

Scandinavian Journal of Rheumatology. Supplement
R J SebaldtC H Goldsmith

Abstract

The purpose of this study was to evaluate the efficacy of intermittent cyclic therapy (ICT) with etidronate in preventing the loss of lumbar vertebral bone mineral density (BMD) in patients taking corticosteroids. The study population was a cohort of patients taking corticosteroids for at least two years for polymyalgia rheumatica, asthma, rheumatoid arthritis, systemic lupus erythematosus or other conditions. A tertiary care university teaching hospital-affiliated rheumatology office practice. Inclusion and exclusion criteria yielded eighty-eight patients taking corticosteroids for at least two years who had not taken estrogen or fluoride and had no causes of secondary osteoporosis. Changes relative to baseline in individual vertebral (L2-L4) BMD measurements after one and two years were compared between patients who had taken ICT with etidronate (n = 42) and those who had not (n = 46). We found that BMD in the lumbar spine increased significantly over baseline in patients who had taken ICT with etidronate, by 3.9% after one year and by 5.6% after two years, whereas it decreased by 3.7-3.8% in patients who had not. We conclude that ICT with etidronate prevents corticosteroid-induced osteoporosis and progressively ameliorates B...Continue Reading

References

Sep 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·B P LukertR G Robinson
Jul 12, 1990·The New England Journal of Medicine·N B WattsM J Yanover

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Citations

Nov 3, 1998·Journal of Internal Medicine·R EastellD J Torgerson
Oct 8, 1998·The Annals of Pharmacotherapy·K H Lucas, S M Davis
Aug 7, 1997·The New England Journal of Medicine·J D AdachiA A Chines
Oct 12, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Jean-Pierre DevogelaerYves Boutsen
Nov 24, 1998·Aging : Clinical and Experimental Research·C Gennari, J Y Reginster
Jul 21, 1998·Endocrinology and Metabolism Clinics of North America·N E Lane, B Lukert
Oct 17, 2002·Rheumatic Diseases Clinics of North America·Marisa Klein-GitelmanEarl D Silverman

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