Intermittent docetaxel chemotherapy is feasible for castration-resistant prostate cancer

Molecular and Clinical Oncology
Haruki KumeYukio Homma

Abstract

This study was conducted with the aim to investigate the feasibility of intermittent treatment with docetaxel chemotherapy for castration-resistant prostate cancer (CRPC). A total of 51 men with CRPC received docetaxel at 75 mg/m(2) every 3 weeks combined with oral dexamethasone 1.0-2.0 mg/day between 2008 and 2013. The prostate-specific antigen (PSA) level was monitored every 3 weeks. Chemotherapy was suspended when the serum PSA level decreased to < 4 ng/ml, with a reduction rate of >50% from the baseline. Treatment was resumed when serum PSA increased to > 2 ng/ml, with an increase rate of >50% from the nadir. Of the 51 cases, 27 (52.9%) qualified for intermittent treatment; 17 patients received two courses of docetaxel chemotherapy and 10 received three courses. The median off-treatment interval was 266 days for the first drug holiday, 129.5 days for the second and 146.5 days for the third. The multivariate analysis indicated low baseline PSA (<median, 30.55 ng/ml; odds ratio = 0.059, P=0.010) and low Gleason score at diagnosis (≤ 7; odds ratio = 0.016, P=0.040) as significant factors for receiving intermittent therapy. The overall survival was better in intermittent cases (hazard ratio = 2.98 by log-rank test, P=0.023). Du...Continue Reading

References

Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Oct 8, 2004·The New England Journal of Medicine·Daniel P PetrylakE David Crawford
Apr 25, 2009·International Journal of Clinical Oncology·Norihito SogaYoshiki Sugimura
Jan 25, 2011·Urology·Ioannis MountziosMeletios A Dimopoulos
Mar 12, 2011·International Urology and Nephrology·Haruki KumeYukio Homma

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