Intermittent Fasting Pretreatment Prevents Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion

The Journal of Nutrition
Yuan HuJunjian Zhang

Abstract

Background: Whether intermittent fasting (IF) pretreatment can prevent vascular cognitive dysfunction remains unknown to our knowledge.Objective: We investigated the effects and underlying mechanisms of IF pretreatment on cognitive dysfunction in a permanent 2-vessel occlusion (2VO) vascular dementia rat model.Methods: Male Wistar rats weighing 200 g were subjected to either IF or ad libitum feeding for 12 wk before 2VO surgery. Rats in the IF protocol underwent alternative-day feed deprivation (FD). Memory of the animals was assessed by using the Morris water maze (MWM) and the novel object recognition (NOR) test 6 wk after the surgery. After behavioral testing, malondialdehyde and glutathione concentrations, superoxide dismutase (SOD) activity, gene expression of antioxidative enzymes, inflammatory protein concentrations, and microglia density were determined in the hippocampus of rats.Results: 2-vessel occlusion operation ad libitum (2VO-AL) rats had significantly longer escape latencies on day 4 of the training phase and spent a lower percentage of time in the target quadrant (25% compared with 38% and 41%) in the MWM, and had lower discrimination ratios (47% compared with 65% and 67%) in the NOR test than 2-vessel operatio...Continue Reading

Citations

May 30, 2019·BMC Cardiovascular Disorders·K OkoshiM P Okoshi
Nov 12, 2019·Frontiers in Physiology·Muzaimi MustaphaMazira Mohamad Ghazali
May 1, 2019·Journal of Lipid and Atherosclerosis·Gwangho Yoon, Juhyun Song
Jul 28, 2018·BioMed Research International·Xin-Chen WangShi-Jian Quan
Jan 20, 2021·The Journal of Physiological Sciences : JPS·Irfannuddin IrfannuddinNoriyuki Koibuchi
Nov 6, 2020·Experimental Gerontology·Stephanie M Muscat, Ruth M Barrientos

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