Intermittent Hypoxia Is Associated With High Hypoxia Inducible Factor-1α but Not High Vascular Endothelial Growth Factor Cell Expression in Tumors of Cutaneous Melanoma Patients

Frontiers in Neurology
Isaac AlmendrosSpanish Sleep Network

Abstract

Epidemiological associations linking between obstructive sleep apnea and poorer solid malignant tumor outcomes have recently emerged. Putative pathways proposed to explain that these associations have included enhanced hypoxia inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) cell expression in the tumor and altered immune functions via intermittent hypoxia (IH). Here, we examined relationships between HIF-1α and VEGF expression and nocturnal IH in cutaneous melanoma (CM) tumor samples. Prospectively recruited patients with CM tumor samples were included and underwent overnight polygraphy. General clinical features, apnea-hypopnea index (AHI), desaturation index (DI4%), and CM characteristics were recorded. Histochemical assessments of VEGF and HIF-1α were performed, and the percentage of positive cells (0, <25, 25-50, 51-75, >75%) was blindly tabulated for VEGF expression, and as 0, 0-5.9, 6.0-10.0, >10.0% for HIF-1α expression, respectively. Cases with HIF-1α expression >6% (high expression) were compared with those <6%, and VEGF expression >75% of cells was compared with those with <75%. 376 patients were included. High expression of VEGF and HIF-1α were seen in 88.8 and 4.2% of samples, respectively. H...Continue Reading

References

Sep 1, 1996·Molecular and Cellular Biology·J A ForsytheG L Semenza
Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·Lena LaviePeretz Lavie
Dec 28, 2002·American Journal of Respiratory and Critical Care Medicine·Christian M KählerChristian Prior
Jan 17, 2003·Stem Cells·David S Goodsell
Feb 17, 2005·Melanoma Research·Alberto M Pisacane, Mauro Risio
Apr 19, 2007·Cancer Metastasis Reviews·Peter Vaupel, Arnulf Mayer
Apr 1, 2008·Cancer Biology & Therapy·Jun-Yan WangBao-Cun Sun
Feb 27, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Silke KuphalAnja-Katrin Bosserhoff
Oct 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xin Lu, Yibin Kang
Apr 7, 2011·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Nadine Rohwer, Thorsten Cramer
Aug 31, 2011·Melanoma Research·Anagnostopoulou KonstantinaKyriaki Aroni
Dec 16, 2011·Nature Reviews. Cancer·Brian KeithM Celeste Simon
Jan 3, 2012·The European Respiratory Journal·I AlmendrosR Farré
May 23, 2012·American Journal of Respiratory and Critical Care Medicine·F Javier NietoRamon Farré
Jan 19, 2013·American Journal of Respiratory and Critical Care Medicine·Luciano F DragerVsevolod Y Polotsky
Mar 19, 2013·Respiratory Physiology & Neurobiology·Isaac AlmendrosRamon Farré
Apr 9, 2013·The Journal of Clinical Investigation·Sara C HannaWilliam Y Kim
Apr 17, 2013·American Journal of Epidemiology·Paul E PeppardKhin Mae Hla
Aug 6, 2013·Lancet·Amy S JordanAtul Malhotra
Dec 11, 2013·The Lancet. Respiratory Medicine·Manuel Sánchez-de-la-TorreFerran Barbé
Jan 30, 2014·American Journal of Respiratory and Critical Care Medicine·Isaac AlmendrosDavid Gozal
Mar 25, 2014·The European Respiratory Journal·Miguel-Ángel Martínez-GarcíaRamón Farré
Oct 4, 2014·Sleep Medicine·Anne Briançon-MarjolletRenaud Tamisier
Feb 16, 2015·The Lancet. Respiratory Medicine·R HeinzerJ Haba-Rubio
Mar 6, 2015·Experimental Dermatology·Alessandra MarconiCarlo Pincelli
Sep 19, 2015·Journal of Thoracic Disease·Karl A Franklin, Eva Lindberg
Oct 9, 2015·Sleep Medicine Reviews·David GozalF Javier Nieto
Mar 5, 2016·Nature Reviews. Endocrinology·Alex Gileles-HillelDavid Gozal
May 11, 2016·Chest·Miguel Ángel Martínez-GarcíaFerrán Barbé
May 12, 2016·Sleep·David GozalBabak Mokhlesi
Jan 1, 2015·Nature Reviews. Disease Primers·Patrick LévyJean-Louis Pépin
Jul 20, 2016·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Milomir GacevićDanilo Vojvodić
Aug 11, 2016·Gastrointestinal Endoscopy·Seohui LeeSeong-Joon Koh
Nov 3, 2016·Cancer Prevention Research·Robert L OwensUNKNOWN UCSD Sleep and Cancer Symposium Group
Dec 22, 2016·JAMA Dermatology·Alex M GlazerDarrell S Rigel
Jan 12, 2017·The Journal of Physiology·Scott K ParksJacques Pouysségur

❮ Previous
Next ❯

Citations

Jul 25, 2019·American Journal of Respiratory and Critical Care Medicine·Miguel Angel Martinez-GarciaDavid Gozal
Aug 11, 2020·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Luana ConteMichele De Benedetto
Feb 28, 2019·Multidisciplinary Respiratory Medicine·Maria R BonsignoreOreste Marrone
Mar 20, 2020·Cellular & Molecular Biology Letters·Sylwia Bartoszewska, James F Collawn
Sep 15, 2020·Current Opinion in Pulmonary Medicine·Oreste Marrone, Maria R Bonsignore
Mar 27, 2021·Current Sleep Medicine Reports·Vinaya SoundararajanAnna B Fishbein
Oct 16, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carolina Cubillos-ZapataUNKNOWN Spanish Sleep Network

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
Getafe

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.