PMID: 7536196Jan 1, 1995Paper

Intermittent interferon and polychemotherapy in metastatic melanoma

Journal of Cancer Research and Clinical Oncology
M S VuoristoA Nevantaus

Abstract

This study was conducted to evaluate the efficacy and the tolerability of a four-drug chemotherapy regimen combined with interferon alpha (IFN) in metastatic melanoma. Between March 1991 and August 1993, 55 patients with advanced melanoma were enrolled for the present multicentre phase II study. Forty-nine patients were eligible and evaluable for toxicity; 48 patients were evaluable for response. The treatment schedule consisted of a 5-day regimen of dacarbazine, vincristine, bleomycin and lomustine, plus 6 x 10(6) IU IFN alpha three times weekly subcutaneously for 2 weeks starting on day 8. The cycle was repeated on day 29. Among the 48 assessable patients, 16 objective responses were seen, yielding a response rate of 33% (95% confidence interval 20%-46%). Seven patients achieved a complete response (CR) of a median of 6+ months (range 1+ to 21+ months) and 9 patients achieved a partial response (PR) of a median of 9 months (range 4-13 months). The median overall survival was 12+ months (range 6+ to 23+ months) for the patients with CR and 15+ months (range 8-20 months) for the patients with PR. Even the survival of the 7 patients with stable disease was fairly long (median 12, range 7-17 months), appearing to be significantly...Continue Reading

References

Dec 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S PyrhönenT Muhonen
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·K A SmithJ M Eccles
Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P GröhnS Numminen
Jan 1, 1992·International Journal of Clinical & Laboratory Research·A C Buzaid, J Murren
Aug 20, 1992·The New England Journal of Medicine·G CocconiP Costa
Feb 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S A Rosenberg
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C G PriceT A Lister
Aug 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C I FalksonH C Falkson
Jan 1, 1987·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·G R McLeodP Hersey
Aug 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S S LeghaR S Benjamin
Jan 1, 1981·Cancer·A B MillerA Winkler
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M VuoristoM Korpela
Feb 1, 1994·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S MitchellS Groshen
Nov 1, 1993·Cancer Immunology, Immunotherapy : CII·D S HoonD L Morton
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M S Aapro

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Citations

Aug 28, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Marios DecatrisKen O'Byrne
Nov 21, 2007·Surgical Oncology Clinics of North America·Nicole M AgostinoPaul J Mosca
Dec 1, 1996·The Surgical Clinics of North America·A N HoughtonP B Chapman
Jun 1, 1996·Annals of Medicine·K Villikka, S Pyrhönen

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