Intermittent morphine treatment causes a protracted increase in cholinergic striatal neurotransmission measured ex vivo

European Journal of Pharmacology
A N SchoffelmeerA H Mulder

Abstract

Considering the long-lasting neuroadaptations that occur in the brain after exposure to drugs of abuse, we found that the facilitatory effect of an EC50 concentration (0.1 microM) of the acetylcholinesterase inhibitor physostigmine, unlike that of the muscarinic receptor agonist oxotremorine, on K(+)-induced [3H]dopamine release from rat striatal slices was enhanced about 2-fold 1 month after cessation of intermittent morphine treatment. Similarly, the inhibitory effect of physostigmine on K(+)-induced [14C]acetylcholine release from the slices was enhanced subsequent to morphine treatment, whereas that of oxotremorine appeared to be unchanged. Therefore, intermittent morphine administration may cause a very long-lasting increase of muscarinic receptor activation by released endogenous acetylcholine in rat striatum, which may play a pivotal role in the enduring character of stimulus hyperresponsiveness after exposure to drugs of abuse.

References

Apr 1, 1974·Analytical Biochemistry·Y SalomonM Rodbell
Sep 1, 1993·Brain Research. Brain Research Reviews·T E Robinson, K C Berridge

❮ Previous
Next ❯

Citations

Nov 28, 2001·The European Journal of Neuroscience·L J VanderschurenA N Schoffelmeer
Aug 2, 2008·Clinical and Experimental Pharmacology & Physiology·Zargham SepehrizadehMousa Sahebgharani
Oct 26, 2006·Pharmacology·Parviz HeidariMohammad-Reza Zarrindast
Mar 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sabine SpijkerAugust B Smit
Aug 1, 1997·Natural Product Reports·K W Bentley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.