Intermittent neural synchronization in Parkinson's disease.

Nonlinear Dynamics
Leonid L RubchinskyRobert M Worth

Abstract

Motor symptoms of Parkinson's disease are related to the excessive synchronized oscillatory activity in the beta frequency band (around 20Hz) in the basal ganglia and other parts of the brain. This review explores the dynamics and potential mechanisms of these oscillations employing ideas and methods from nonlinear dynamics. We present extensive experimental documentation of the relevance of synchronized oscillations to motor behavior in Parkinson's disease, and we discuss the intermittent character of this synchronization. The reader is introduced to novel time-series analysis techniques aimed at the detection of the fine temporal structure of intermittent phase locking observed in the brains of parkinsonian patients. Modeling studies of brain networks are reviewed, which may describe the observed intermittent synchrony, and we discuss what these studies reveal about brain dynamics in Parkinson's disease. The parkinsonian brain appears to exist on the boundary between phase-locked and nonsynchronous dynamics. Such a situation may be beneficial in the healthy state, as it may allow for easy formation and dissociation of transient patterns of synchronous activity which are required for normal motor behavior. Dopaminergic degener...Continue Reading

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Citations

Jun 11, 2017·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Shivakeshavan Ratnadurai-GiridharanLeonid L Rubchinsky
Mar 4, 2020·The International Journal of Neuroscience·Rutvi Prajapati, Isaac Arnold Emerson
Jul 15, 2015·The European Journal of Neuroscience·Sungwoo AhnLeonid L Rubchinsky
Jan 10, 2017·Frontiers in Computational Neuroscience·Sungwoo AhnLeonid L Rubchinsky
Sep 12, 2019·Frontiers in Computational Neuroscience·Zonglu He
Apr 1, 2020·PLoS Computational Biology·Jyotika BahugunaArvind Kumar
Jan 14, 2021·Journal of Neural Engineering·Linda Katherine Wood FordBrendan Ames
Sep 11, 2017·Current Opinion in Neurobiology·Jonathan E Rubin
Apr 13, 2021·Frontiers in Neural Circuits·Abolfazl Ziaeemehr, Alireza Valizadeh
Jul 13, 2021·Chaos·Quynh-Anh Nguyen, Leonid L Rubchinsky
Jul 10, 2017··Chiara FavarettoAngelo Cenedese

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