Intermittent parenteral administration of endotoxin triggers metabolic and immunological alterations typically associated with displaced abomasum and retained placenta in periparturient dairy cows

Journal of Dairy Science
Q ZebeliB N Ametaj

Abstract

This study sought to investigate the effects of induced intermittent endotoxemia on plasma mediators of carbohydrate and lipid metabolism, humoral immunity, and clinical health status in periparturient dairy cows. Sixteen pregnant Holstein cows were blocked by parity and day of calving, and were randomly allocated to 1 of 2 different treatment groups. Eight cows were infused intravenously (i.v.) with 100mL of sterile saline and served as the control group (CON). The other 8 cows were infused i.v. with 100mL of sterile saline containing 3 increasing doses of lipopolysaccharide (LPS), from Escherichia coli O111:B4, for 3 consecutive weeks during the 2 wk before and 1 wk after parturition as follows: (1) 0.01 μg of LPS/kg of body weight (BW) on d -14 and -10; (2) 0.05 μg of LPS/kg of BW on d -7 and -3; and (3) 0.1 μg of LPS/kg of BW on d 3 and 7 postpartum. Nine blood samples were collected during the experimental period (i.e., from -14 to 28 d postpartum) and analyzed for calcium, zinc, iron, copper, glucose, lactate, β-hydroxybutyrate (BHBA), nonesterified fatty acids (NEFA), cholesterol, insulin, cortisol, serum amyloid A (SAA), lipopolysaccharide-binding protein (LBP), haptoglobin (Hp), and anti-LPS IgA, IgG, and IgM. Results ...Continue Reading

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May 23, 2014·Animal : an International Journal of Animal Bioscience·James K Drackley, F C Cardoso
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Related Concepts

Abomasum
Blood Chemical Analysis
Bos indicus
Dairying
Ingestion
Polyglobin
IgM2
Immune System
Resistance, Natural
Parenteral Infusion

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