PMID: 2494240Mar 15, 1989Paper

Intermittent transdermal nitroglycerin therapy in the treatment of chronic stable angina

Journal of the American College of Cardiology
H DeMots, S P Glasser

Abstract

The effectiveness of an intermittent regimen of transdermal nitroglycerin in chronic stable angina was evaluated in 206 patients using serial treadmill testing. After a placebo stabilization phase, patients were randomized to 4 weeks of double-blind treatment with transdermal nitroglycerin, 10 or 20 cm2 (equivalent to 5 or 10 mg/24 h) (Group A); transdermal nitroglycerin, 30 or 40 cm2 (equivalent to 15 or 20 mg/24 h) (Group B), or placebo. Patches were applied at 8:00 AM and removed at 8:00 PM each day throughout the study. Treadmill testing was performed 0, 4, 8 and 12 h after patch application at baseline (day 0) and on days 1, 15 and 29. After short-term application of the transdermal patches, treadmill walking time was greater for patients in both Group A and Group B than for the placebo group at all time points tested; differences from placebo were statistically significant at 12 h for Group A and at 4, 8 and 12 h for Group B. After 2 and 4 weeks of long-term therapy, treadmill walking time was again greater for Group B than for the placebo group at all postapplication time points; differences from placebo reached statistical significance at 4 h (2 weeks) and 8 h (2 and 4 weeks). The improvement in the treadmill walking ti...Continue Reading

References

Aug 1, 1987·The American Journal of Cardiology·J C CowanD G Julian
Sep 1, 1987·Journal of the American College of Cardiology·R LukeR Coxon
May 1, 1985·Journal of the American College of Cardiology·M SullivanV Froelicher
Sep 1, 1984·The American Journal of Cardiology·J O Parker, H L Fung

❮ Previous
Next ❯

Citations

Mar 1, 1996·Cardiovascular Drugs and Therapy·T O Klemsdal, K Gjesdal
Jan 1, 1991·European Journal of Clinical Pharmacology·B W KarlsonG Olsson
Oct 1, 1994·Cardiovascular Drugs and Therapy·U Thadani, L H Opie
Aug 1, 1994·Cardiovascular Drugs and Therapy·U Thadani, R J Lipicky
Aug 1, 1994·Cardiovascular Drugs and Therapy·U Thadani, R J Lipicky
Dec 3, 2011·Cardiovascular Drugs and Therapy·Francesco Iachini BellisariiRaffaele De Caterina
Feb 1, 1993·Journal of the American College of Cardiology·E RossettiS L Chierchia
Aug 10, 2000·Journal of the American College of Cardiology·T MünzelT Meinertz
Dec 29, 2000·Journal of the American College of Cardiology·D Hébert, J Y Lam
Feb 24, 2001·Journal of the American College of Cardiology·E R AzevedoJ D Parker
Mar 30, 2002·Journal of the American College of Cardiology·John O ParkerWayne H Kaesemeyer
Jun 12, 2003·Journal of the American College of Cardiology·Senta MüllerGeorg Kojda
Oct 1, 1990·Journal of the American College of Cardiology·M Packer
May 1, 1992·Applied Nursing Research : ANR·M RyanJ C Wandel
Feb 19, 1998·The New England Journal of Medicine·J D Parker, J O Parker
Aug 11, 2006·Current Opinion in Cardiology·Ami B Bhatt, Peter H Stone
Aug 1, 1992·British Journal of Clinical Pharmacology·J C Cowan
Jan 1, 1992·British Journal of Clinical Pharmacology·J O Parker
Jan 1, 1992·British Journal of Clinical Pharmacology·G Olsson, J Allgén
Jun 1, 1991·Clinical and Experimental Pharmacology & Physiology·Z Y DuO L Woodman
May 1, 1995·Clinical and Experimental Pharmacology & Physiology·C L ZhangJ D Horowitz
Apr 7, 2005·Clinical and Experimental Pharmacology & Physiology·Elizabeth A KellyJohn D Horowitz
Nov 1, 1992·Postgraduate Medical Journal·S R Maxwell, M J Kendall
Jun 25, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Atsushi NakahiraShigefumi Suehiro
Oct 20, 2004·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Ken KanamasaUNKNOWN Secondary Prevention Group
Feb 8, 2007·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hideki MoriiKen Kanamasa
Mar 26, 2014·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Udho Thadani
Aug 1, 1991·Journal of Clinical Pharmacology·D Rinde-HoffmanD K Arnett
Aug 4, 1998·International Journal of Cardiology· Martsevich SYuV I Metelitsa
Oct 1, 1990·Australian and New Zealand Journal of Medicine·D W Whalley, K J Hellestrand
May 12, 2000·British Journal of Pharmacology·G Abou-MohamedR W Caldwell
Mar 21, 2012·The Canadian Journal of Cardiology·John D Parker, John O Parker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.