PMID: 8473618Apr 1, 1993Paper

Intermodulation distortion (F2-F1) in inner hair cell and basilar membrane responses

The Journal of the Acoustical Society of America
A L Nuttall, D F Dolan

Abstract

Round window (RW) recordings in guinea pigs show a large response at the frequency of the quadratic difference tone (QDT) at F2-F1 for high-frequency (> 8 kHz) tone pairs. The magnitude of the RW response is dependent on frequency and level of the primaries. The QDT cochlear microphonic produced is largest for primaries with a frequency separation of approximately 900 Hz. Its source is probably the local activity of hair cells in basal cochlear locations where the high-frequency tones interact. QDT measurements from locations inside the organ of Corti show that the magnitude of the QDT is largest in the inner hair cell (IHC) region and monotonically increases as the difference in the frequency of the primaries decreases. Measured as IHC intracellular ac receptor potential, the QDT appears to be the result of a mechanical stimulus to the cell rather than as an inherent property of the nonlinear transduction in the IHC. However, QDT of the same form is not evident in the velocity responses of the basilar membrane. These results suggest that the outer hair cells (OHC) produce a strong quadratic distortion product mechanical force to stimulate inner hair cells. This mechanical drive may not be present, or is a weak component, in ba...Continue Reading

Citations

Sep 28, 2010·Journal of the Association for Research in Otolaryngology : JARO·William P Shofner
Aug 1, 1992·Current Opinion in Neurobiology·M A Ruggero
Jul 16, 2002·Hearing Research·Anders FridbergerAlfred Nuttall
Jun 5, 2003·Hearing Research·Yuan ZouTianying Ren
Jan 18, 2007·The Journal of the Acoustical Society of America·Colleen G Le PrellDavid F Dolan
Feb 25, 2000·The Journal of the Acoustical Society of America·D Brass
Feb 12, 2009·The Journal of the Acoustical Society of America·Lin Bian, Shixiong Chen
Mar 3, 2011·The Journal of the Acoustical Society of America·Harisadhan PatraLawrence L Feth
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Sep 25, 2019·ELife·Anna VavakouMarcel van der Heijden

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