PMID: 3768322Aug 26, 1986Paper

Intermolecular cross-linking and stereospecific molecular packing in type I collagen fibrils of the periodontal ligament

Biochemistry
M YamauchiG L Mechanic

Abstract

A trypsin digest of denatured NaB3H4-reduced native bovine periodontal ligament was prepared and fractionated by gel filtration and cellulose ion-exchange column chromatography. Prior to trypsin digestion, a complete acid hydrolysate was subjected to analyses for nonreducible stable and reducible intermolecular cross-links. Minute amounts of the former and significant amounts of the reduced cross-links dihydroxylysinonorleucine (1.1 mol/mol of collagen), hydroxylysinonorleucine (0.9 mol/mol of collagen), and histidinohydroxymerodesmosine (0.6 mol/mol of collagen) were found. The covalent intermolecular cross-linked two-chained peptides that were isolated were subjected to amino acid and sequence analyses. The structures for the different two-chained linked peptides were alpha 1CB4-5(76-90)[Hyl-87] X alpha 1CB6-(993-22c)[Lysald-16c], alpha 1CB4-5(76-90)[Hyl-87] X alpha 1CB6(993-22c)[Hylald-16c], alpha 2CB4(76-90)[Hyl-87] X alpha 1CB6(993-22c)[Lysald-16c], and alpha 2CB4(76-90)[Hyl-87] X alpha 1CB6(993-22c)[Hylald-16c]. The cross-link in each peptide was glycosylated. This is the first characterization by sequence analysis of a cross-link involving Hyl-87 in an alpha 2 chain in collagen. A stoichiometric conversion of residue 16c...Continue Reading

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Citations

Dec 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Veis
May 1, 1995·Calcified Tissue International·Y HashimotoM Yamauchi
Sep 18, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M Saito, K Marumo
Sep 4, 2007·Annals of Biomedical Engineering·Thomas L WillettJ Michael Lee
Dec 1, 1990·Journal of the Neurological Sciences·S OnoM Yamauchi
Mar 9, 2004·Archives of Oral Biology·S NakornchaiM Yamauchi
Feb 1, 1997·Archives of Oral Biology·J T WrightM Yamauche
May 24, 2003·Biochemical and Biophysical Research Communications·Katsuhiro UzawaMitsuo Yamauchi
Dec 16, 1998·Journal of the Neurological Sciences·S OnoM Yamauchi
Oct 16, 1999·Journal of the Neurological Sciences·S OnoK Nagao
Apr 1, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·Z Deyl, I Miksík
Oct 7, 1997·Bone·T SaitoM A Crenshaw
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·W TraubS Weiner
Nov 1, 1992·Acta Neurologica Scandinavica·S Ono, M Yamauchi
Mar 12, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T SaitoM A Crenshaw
Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K UzawaM Yamauchi
Jul 14, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R A BankR J Sakkers
Aug 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T SaitoM A Crenshaw
Sep 8, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M H WassenR A Bank
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·E P PaschalisM Yamauchi
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Masashi ShiibaMitsuo Yamauchi
May 6, 2014·BioMed Research International·Hiroko NagaokaMitsuo Yamauchi
Apr 4, 2014·Acta Odontologica Scandinavica·Takashi MatsuuraHironobu Sato
Nov 11, 2008·Connective Tissue Research·Kentaro TokutomiMitsuo Yamauchi
Mar 27, 2002·Connective Tissue Research·M ShiibaM Yamauchi
Jan 1, 1989·Connective Tissue Research·E P KatzG L Mechanic
Jan 1, 1993·Connective Tissue Research·Y KubokiH Hirano
Jan 1, 1993·Connective Tissue Research·M Yamauchi, E P Katz
Jan 1, 1995·Connective Tissue Research·J T WrightM Yamauchi
Apr 25, 2007·Connective Tissue Research·Michitsuna KatafuchiMitsuo Yamauchi
Aug 5, 2009·Micron : the International Research and Review Journal for Microscopy·Luciana Borges RetamosoOrlando Motohiro Tanaka
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eleftherios P PaschalisAdele L Boskey
Jul 3, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Suchaya PornprasertsukMitsuo Yamauchi
Aug 19, 2007·European Journal of Oral Sciences·Kostas VerdelisAdele L Boskey
Feb 4, 2009·Journal of Biomedical Materials Research. Part a·Shih-Youeng ChuangJaw-Lin Wang

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