Intermolecular Interaction between a Synthetic Pseudoceramide and a Sterol-Combined Fatty Acid

Journal of Colloid and Interface Science
H MizushimaT Suzuki

Abstract

To better understand the phase behavior of a pseudoceramide (SLE), a potential skin moisturizer and/or a drug carrier, we investigated the lipid-lipid interaction between SLE and a sterol-combined fatty acid (CEOS), which has a sterol ring and a carboxyl group in a molecule. X-ray analysis showed that a hexagonal packing (4.15 A spacing) and a liquid-like packing (4.5 A spacing) coexisted within the hydrocarbon chains of the SLE/CEOS (1/1 mole) lipid mixture. The structural characteristics were very similar to those of the SLE/stearic acid/cholesterol (1/1/1 mole) system, which was in a stable lamellar alpha-phase. However, in the SLE/stearic acid (1/1 mole) system, there was only a strong hexagonal reflection in the wide-angle X-ray profile. The melting enthalpy (23.9 kJ mol-1) and entropy (75.0 J mol-1 K-1) of the SLE/CEOS system were also smaller than those (DeltaHm = 43.9 kJ mol-1, DeltaSm = 131.6 J mol-1 K-1) of the SLE/stearic acid system. The X-ray data along with the DSC results suggested that the sterol ring of CEOS molecule contributed to the enhancement of molecular motion or the decrease in the molecular packing of lipids. A strong hydrogen bond between the carboxyl group of CEOS and the amide group of SLE molecule ...Continue Reading

References

Sep 30, 1991·Biochimica Et Biophysica Acta·W Abraham, D T Downing
May 1, 1985·The Journal of Investigative Dermatology·P W WertzD T Downing
Apr 21, 1987·Biochemistry·G M GoldenR O Potts
Nov 1, 1986·The Journal of Investigative Dermatology·P W WertzD T Downing
Oct 1, 1971·Physiological Reviews·R J Scheuplein, I H Blank
Jan 1, 1981·International Journal of Dermatology·P M Elias
Feb 1, 1995·Lipids·C H HanT S Wiedmann
Aug 1, 1993·The Journal of Clinical Investigation·M Mao-QiangK R Feingold
May 1, 1963·Archives of Dermatology·H D ONKEN, C A MOYER
Jun 1, 1983·The Journal of Investigative Dermatology·P M Elias

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Citations

Jun 25, 2010·Journal of Pharmaceutical Sciences·Philip J SasseneAnette Müllertz
Jun 23, 2009·Colloids and Surfaces. B, Biointerfaces·Do-Hoon KimEun Chul Cho
Apr 16, 2008·Chemistry and Physics of Lipids·C MerleA Baillet-Guffroy
Feb 6, 2010·Photochemistry and Photobiology·Chloé MerleArlette Baillet-Guffroy

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