Intermuscular coherence in Parkinson's disease: effects of subthalamic nucleus stimulation

Neuroreport
J MarsdenPeter Brown

Abstract

It remains unclear how high frequency stimulation of the subthalamic nucleus (STN) improves parkinsonism. We hypothesized that stimulation may affect the organization of the cortical drive to voluntarily activated muscle. Normally this is characterized by oscillations at 15-30 Hz, manifest in coherence between muscles in the same frequency band. We therefore investigated the effects of STN stimulation on electromyographic (EMG) activity in co-contracting distal arm muscles in nine subjects with Parkinson's disease off drugs. Without stimulation, coherence between EMG signals was diminished at 15-30 Hz compared with nine controls. STN stimulation increased coherence in the 15-30 Hz band, so that it approached that in healthy subjects. The results suggest that STN stimulation facilitates the normal cortical drive to muscles.

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Citations

Oct 3, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Carla CordivariPeter Brown
Dec 10, 2003·Current Opinion in Neurobiology·Stephan Salenius, Riitta Hari
Jun 5, 2003·NeuroImage·Robert S TurnerJohn M Hoffman
Mar 21, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marlieke ScholtenDaniel Weiss
Oct 15, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel WeissAlireza Gharabaghi
Apr 12, 2016·Frontiers in Neuroscience·Kevin KernAlireza Gharabaghi
Jun 28, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Christian DuvalAbbas F Sadikot
Jul 15, 2016·Brain : a Journal of Neurology·Ettore A AccollaAndrea A Kühn
Apr 2, 2005·Nature Reviews. Neuroscience·Alfons Schnitzler, Joachim Gross
May 17, 2003·Journal of Neurophysiology·Pascal Grosse, Peter Brown
Sep 29, 2006·Journal of Neurophysiology·Moran WeinbergerJonathan O Dostrovsky
May 2, 2012·The Journal of Physiology·B PollokM Südmeyer
Feb 6, 2015·Journal of Neurophysiology·Kevin W McCairn, Robert S Turner
Oct 27, 2017·Frontiers in Neuroscience·Kimberly B HoangDennis A Turner

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