PMID: 11329578May 1, 2001Paper

Internal anal sphincter achalasia: outcome after internal sphincter myectomy

Journal of Pediatric Surgery
D De CaluwéPrem Puri

Abstract

Internal anal sphincter achalasia (IASA), also referred to as ultrashort segment Hirschsprung's disease (HD), is a clinical condition with presentation similar to HD, but with the presence of ganglion cells on rectal biopsy. The diagnosis of IASA is made on anorectal manometry, which shows the absence of rectosphincteric reflex on rectal balloon inflation. Altered intramuscular innervation has been reported in IASA. The purpose of this study was to review the outcome after internal sphincter myectomy in patients with IASA. Fifteen consecutive patients (age range, 2 years to 12 years) with IASA underwent posterior internal sphincter myectomy. All patients presented with severe constipation with or without soiling. The diagnosis of IASA was made by anorectal manometry. HD was excluded in these cases by the presence of ganglion cells and normal acetylcholinesterase activity on suction rectal biopsies. Internal sphincter (IS) specimens were examined using immunohistochemistry for the general neuronal marker PGP 9.5 and synapsin 1 (a presynaptic marker) and using general histochemistry for NADPH-diaphorase. All patients underwent follow-up for periods from 2 years to 6 years. PGP 9.5, synapsin 1 and NADPH-diaphorase positive nerve f...Continue Reading

Citations

Sep 27, 2006·Pediatric Surgery International·Thambipillai Sri ParanPrem Puri
Aug 15, 2009·Pediatric Surgery International·Reshma Doodnath, Prem Puri
Mar 3, 2010·Pediatrics in Review·Marc A Levitt, Alberto Peña
Feb 4, 2016·Arquivos De Gastroenterologia·Mehran PeyvastehHazhir Javaherizadeh
May 10, 2016·Indian Pediatrics·Ujjal Poddar
Sep 1, 2005·Journal of Pediatric Gastroenterology and Nutrition·Marc A Levitt, Alberto Peña
Nov 9, 2006·Indian Journal of Pediatrics·Narayanan Venkatasubramani, Manu R Sood
May 15, 2003·Current Treatment Options in Gastroenterology·William M. Belknap
Dec 24, 2004·Pediatric Surgery International·M HeikkinenR J Rintala
Mar 5, 2009·The American Journal of Gastroenterology·Bruno P ChumpitaziSamuel Nurko
Oct 15, 2013·Journal of Pediatric Gastroenterology and Nutrition·Khoa TranJaime Belkind-Gerson
Apr 30, 2008·Pediatric Surgery International·Katy IraniAllan M Goldstein
Sep 10, 2003·Journal of Pediatric Gastroenterology and Nutrition·Paola CiamarraCarlo Di Lorenzo
Aug 15, 2013·Pediatric Surgery International·Florian Friedmacher, Prem Puri
Oct 31, 2007·Pediatric Surgery International·Udo RollePrem Puri
Dec 11, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Desiree F BaalemanPeter L Lu
Dec 23, 2004·Current Problems in Surgery·Roshini Dasgupta, Jacob C Langer
Jan 22, 2005·Seminars in Pediatric Surgery·Prem Puri, Udo Rolle
Sep 29, 2009·Seminars in Pediatric Surgery·Reshma Doodnath, Prem Puri

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.