Internal anal sphincter augmentation for fecal incontinence using injectable silicone biomaterial

Diseases of the Colon and Rectum
A J MaloufM A Kamm

Abstract

A disrupted or weak internal anal sphincter can lead to passive fecal incontinence. This muscle is not amenable to direct surgical repair. Previous preliminary attempts to restore functional continuity have included a cutaneous flap to fill an anal canal defect, and injection therapy using polytetrafluoroethylene, collagen, or autologous fat. Urologists have also used injections of collagen or silicone to enhance bladder neck function. This pilot study aimed to assess the efficacy of single or multiple injections of the silicone-based product Bioplastique for the symptoms of passive fecal incontinence caused by an anatomically disrupted or intact but weak internal anal sphincter. Ten patients (6 females; median age, 64, range, 41-80 years) with passive incontinence secondary to a weak (n = 6) or disrupted (n = 4) internal anal sphincter were injected either circumferentially or at a single site, respectively. Patients were assessed before and six weeks after treatment by clinical assessment, two-week bowel diary card, anorectal physiologic testing, and endoanal ultrasound. Patients failing to show improvement after the first injection were offered a second injection six weeks after the first injection. Clinical assessment was f...Continue Reading

References

Jan 1, 1992·Aesthetic Plastic Surgery·A A Beisang, R A Ersek
Feb 1, 1991·International Journal of Colorectal Disease·S J Burnett, C I Bartram
Jan 1, 1989·International Journal of Colorectal Disease·B LestarR Kerremans
Jan 1, 1995·International Journal of Colorectal Disease·A F EngelR J Nicholls
Jun 1, 1995·Diseases of the Colon and Rectum·A Shafik
Jul 1, 1994·The British Journal of Surgery·A F EngelP R Hawley
Jul 1, 1994·The British Journal of Surgery·P B LoderR K Phillips
Aug 1, 1996·Diseases of the Colon and Rectum·B P GeerdesC G Baeten
Dec 1, 1996·Diseases of the Colon and Rectum·W D WongD A Rothenberger
Dec 1, 1996·Diseases of the Colon and Rectum·P A LehurJ M Buzelin
Feb 1, 1997·The British Journal of Surgery·R MorganN D Carr
Jan 1, 1997·International Journal of Colorectal Disease·A M LeroiP R Hawley
Aug 6, 1998·The British Journal of Surgery·D KumarJ E Bland
Oct 17, 1998·Plastic and Reconstructive Surgery·C BernardiM Pescatori
Feb 23, 1999·The British Journal of Surgery·I SielezneffS Douglas
Mar 25, 2000·Diseases of the Colon and Rectum·C J VaizeyR J Nicholls
Jun 22, 2000·Annals of Surgery·A J MaloufM A Kamm

❮ Previous
Next ❯

Citations

Mar 23, 2010·Diseases of the Colon and Rectum·Hanne B MichelsenSteen Buntzen
Feb 4, 2010·International Journal of Colorectal Disease·Thomas C DuddingMichael A Kamm
Nov 12, 2010·International Journal of Colorectal Disease·John M Findlay, Charles Maxwell-Armstrong
Feb 17, 2006·Diseases of the Colon and Rectum·Miranda K Y Chan, Joe J Tjandra
Aug 4, 2007·Diseases of the Colon and Rectum·Joe J TjandraUNKNOWN Standards Practice Task Force of The American Society of Colon and Rectal Surgeons
Sep 18, 2007·Diseases of the Colon and Rectum·Jane J Y TanJoe J Tjandra
Sep 4, 2004·Current Treatment Options in Gastroenterology·Licia Pensabene, Samuel Nurko
Sep 6, 2012·Updates in Surgery·Zeiad I HussainStevan Stojkovic
Jan 9, 2003·Journal of the American College of Surgeons·Steven D Wexner, Dana R Sands
Oct 29, 2002·Current Opinion in Obstetrics & Gynecology·Nicholas Rieger
Feb 9, 2013·Diseases of the Colon and Rectum·S MaslekarP M Sagar
Apr 17, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Y MaedaM A Kamm
Jul 5, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·F de la PortillaE Espinosa
May 9, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·M M SoerensenS Laurberg
Jul 22, 2008·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J J TjandraH C H Yeh
Mar 27, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C LuoI P Bissett
Dec 8, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A HotourasC L H Chan
Apr 25, 2014·Gastroenterology Report·Fernando de la Portilla
Apr 26, 2002·Seminars in Pediatric Surgery·A A Darakhshan, N S Williams
Dec 2, 2015·The British Journal of Surgery·C RattoA Parello
Aug 11, 2012·The Urologic Clinics of North America·Matthew Fulton, Kenneth M Peters
Aug 15, 2006·The Surgical Clinics of North America·Benjamin PersonSteven D Wexner
Apr 27, 2005·The British Journal of Surgery·C J Vaizey, M A Kamm
Oct 19, 2006·The British Journal of Surgery·S G StojkovicP M Sagar
Apr 19, 2007·Alimentary Pharmacology & Therapeutics·L SiproudhisF Lainé
Jan 16, 2007·The British Journal of Surgery·D R ChatoorA V Emmanuel
Jul 28, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Y MaedaM A Kamm
Sep 20, 2011·The British Journal of Surgery·C RattoP Giordano
Oct 4, 2011·The British Journal of Surgery·Z I HussainS G Stojkovic
Jun 19, 2010·ANZ Journal of Surgery·Jacqueline H StephensPeter J Hewett
Aug 18, 2004·Lancet·Robert D MadoffAnn C Lowry
Apr 28, 2007·International Journal of Surgery·K S GurusamyH Benziger
May 27, 2017·Journal of Anatomy·Hugo Alves de SousaSelma Aparecida Souza Kuckelhaus
Apr 23, 2005·Surgical Innovation·Benjamin Person, Steven D Wexner
Mar 2, 2013·The Cochrane Database of Systematic Reviews·Yasuko MaedaChristine Norton
Jul 14, 2010·British Journal of Nursing : BJN·John Findlay, Charles Maxwell-Armstrong

❮ Previous
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