Internal biliary drainage improves decreased number of gut mucosal T lymphocytes and MAdCAM-1 expression in jaundiced rats

Surgery
Tomohide SanoYoshikazu Kuroda

Abstract

Although the effect of preoperative biliary drainage in patients with obstructive jaundice is controversial, bacterial or endotoxin translocation is one of the main postoperative problem in jaundiced patients. Failure in gut barrier functions causes bacterial translocation; homing and distribution of T lymphocytes in the intestinal lamina propria are important for gut mucosal immune defense. This study was performed to examine whether bile regulates the numbers of T lymphocyte subsets or the expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in experimental jaundice in rats with and without external and internal biliary drainage. Four groups of Wistar rats were used: those that received a sham operation (SHAM), common bile duct ligation (CBDL), CBDL followed by external drainage (ED), and CBDL followed by internal drainage (ID). Numbers of CD4(+) and CD8(+) T lymphocytes and MAdCAM-1-positive cells in the lamina propria were counted immunohistochemically in the specimens of jejunum and ileum of each group. Bacterial translocation was examined by culturing from the mesenteric lymph node complex isolated from rats in each group. A significant decrease in numbers of CD4(+) and CD8(+) T lymphocytes and MAdCAM-1-pos...Continue Reading

References

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Citations

Oct 19, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yuko YoshidaYonson Ku
Jun 18, 2009·World Journal of Gastroenterology : WJG·Rui-Ping ZhangDi-Jiong Wu
Jan 18, 2013·World Journal of Gastroenterology : WJG·Xin-Hua ZhuYi-Tao Ding
Dec 27, 2008·Journal of Hepato-biliary-pancreatic Surgery·Giuseppe Garcea, G J Maddern
Feb 3, 2009·Journal of Hepato-biliary-pancreatic Surgery·Yasuhiro FujinoYoshikazu Kuroda
Dec 7, 2017·Gastroenterology Research and Practice·Petros YpsilantisConstantinos Simopoulos
Mar 27, 2007·Journal of Hepato-biliary-pancreatic Surgery·Yukihiro YokoyamaYuji Nimura
Nov 20, 2012·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Nicolas GolseEric Vibert
Sep 13, 2006·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Emin GurleyikElif Ozturk
Jun 6, 2017·Annals of Surgical Treatment and Research·Xin HuangJia-Hong Dong

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